N-sulfonyl hydroxamic acid derivatives as inhibitors of cd23

A compound of formula (IA):

• 15
• wherein:
• R1 is bicyclyl or heterobicyclyl;
• R2 and R3 are each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, (C1-6)alkylthio, (C2-6)alkenylthio, (C2-6)alkynylthio, aryloxy, arylthio, heterocyclyloxy, heterocyclythio, (C1-6)alkoxy, (C1-6)alkenyloxy, aryl(C1-6)alkoxy, aryl(C1-6)alkylthio, amino, mono- or di-(C1-6)alkylamino, acylamino, sulfonylamino, cycloalkyl, cycloalkenyl, carboxylic acid (C1-6) ester, hydroxy, halogen, carboxamide:
• CONR8R9 where R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl and heterocyclyl and includes R8 and R9 as part of a heterocyclyl group, or R2 and R3 together form a cyclic alkyl or alkenyl;
• R4 and R5 are each independently aryl, heteroaryl, heterocyclyl, alkoxy, alkyl, hydroxy or optionally substituted amino;
• R6 and R7 are each hydrogen or together form a fused aryl ring;
• and
• m and n are each independently from 0 to 2;
• with the proviso that when n−1 neither R4 nor R5 is hydroxy, alkoxy or amino.

A compound selected from the group consisting of:

• (R)-1-(Benzo[b]thiophen-5-ylmethanesulfonyl)piperidine-2-carboxylic acid N-hydroxyamide;
• (R)-1-(Naphthalen-2-ylmethanesulfonyl)piperidine-2-carboxylic acid N-hydroxyamide;
• (R)-2-(Naphthalen-2-ylmethanesulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-carboxylic acid N-hydroxyamide;
• and
• (R)-2-(Benzo[b]thiophen-5-ylmethanesulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-carboxylic acid N-hydroxyamide.