Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes

A compound of formula (II):

• 121
• wherein
• m is 1, 2 or 3,
• n is 0, 1, 2 or 3,
• R1 and R2 independently are
• hydrogen,
• C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl, which may optionally be substituted with one or more substituents selected from C3-8-cycloalkyl, C5-8-cycloalkenyl, halogen and hydroxyl, or
• C3-8-cycloalkyl or C5-8-cycloalkenyl, which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, C1-6-alkyl, C2-6-alkenyl and C2-6-alkynyl,
• or R1 and R2 together form a C3-6-alkylene bridge or a C3-6-alkenylene bridge, which may optionally be substituted with one or more substituents selected from halogen and hydroxyl,
• R11 and R12 independently are
• hydrogen,
• C1-6-alkyl, which may optionally be substituted with one or more substituents selected from C3-8-cycloalkyl, C5-8-cycloalkenyl, halogen and hydroxyl, or
• C3-8-cycloalkyl or C5-8-cycloalkenyl, which may optionally be substituted with one or more substituents selected from halogen and hydroxyl,
• X is
• 122
• R3, R4, R5, R6, R7, R8, R9 and R10 independently are
• hydrogen, halogen, cyano, —NR15R16, hydroxyl, carbamoyl, carboxyl, —CF3, —OCF3, carboxyl, amidino, guanidino or nitro, or
• C1-6-alkoxy, C1-6-alkyl, C1-7-alkanoyl, C1-6-alkylcarbamoyl, di-C1-6-alkylcarbamoyl, C1-6-alkyloxycarbonyl, C3-8-cycloalkyl, C3-8-cycloalkanoyl, C3-8-cycloalkylcarbamoyl, C3-8-cycloalkyl-oxycarbonyl, C1-6-alkylthio, C1-6-alkylsulfinyl, C1-6-alkylsulfonyl, C1-6-alkylsulfonyl-O-, aryl, aroyl, aryloxy, aryloxycarbonyl, arylthio, arylsulfanyl, arylsulfanyl, heteroaryl, heteroaroyl, or heteroaryloxy which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, cyano and —NR15R16,
• R15 and R16 independently are
• hydrogen or carbamoyl,
• C1-6-alkyl, which may optionally be substituted with one or more substituents selected from C3-8-cycloalkyl, C5-8-cycloalkenyl, halogen, hydroxyl, cyano and amino, or
• C3-8-cycloalkyl, C5-8-cycloalkenyl, C1-6-alkylcarbamoyl, di-C1-6-alkylcarbamoyl or C1-6-alkyloxycarbonyl, which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, cyano, amino, C1-6-alkyl, C2-6-alkenyl and C2-6-alkynyl,
• or R15 and R16 together form a C3-6-alkylene bridge or a C3-6-alkenylene bridge, which may optionally be substituted with one or more substituents selected from halogen and hydroxyl,
• or two or more of R3 and R4, R4 and R5, R5 and R6, R6 and R7, R7 and R8, R8 and R9, R9 and R6, and R8 and R10 together form a bridge selected from —OCH2O—, —OCH2CH2O—, —OCH2CH2CH2O— and C3-5-alkylene,
• or R11 and R3, R11 and R7, or R11 and R10 together form a bridge selected from —O—, —S—, —CH2—, —C(═O)—, —CH(OH)—, —NR13—, —OCH2— and —CH2O—,
• R13 is
• hydrogen,
• C1-6-alkyl, which may optionally be substituted with one or more substituents selected from C3-8-cycloalkyl, C5-8-cycloalkenyl, halogen, hydroxyl, cyano and amino,
• C3-8-cycloalkyl or C5-8-cycloalkenyl, which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, cyano, amino, C1-6-alkyl, C2-6-alkenyl and C2-6-alkynyl,
• —Y— is —CH2—, —C(═O)—, —NR14—, —O—, —S—, —CH2O—, —OCH2— or —CH(OH)—,
• R14 is
• hydrogen,
• C1-6-alkyl, which may optionally be substituted with one or more substituents selected from C3-8-cycloalkyl, C5-8-cycloalkenyl, halogen, hydroxyl, cyano and amino,
• C3-8-cycloalkyl or C5-8-cycloalkenyl, which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, cyano and amino,
• R17 is hydrogen, C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl,
• R18 and R19 independently are hydrogen, halogen, hydroxyl, amino, C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl,
• as well as any diastereomer or enantiomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.