Oxindole derivatives

A compound of Formula I

• 23
• or a salt, solvate, or a physiologically functional derivative thereof:
• wherein:
• R1 is (CR4R5)nNR2R3;
• n is 1 or 2;
• R2 and R3 are independently hydrogen, C1-6 alkyl, C1-6 alkenyl, C1-6 alkoxy-C1-6 alkyl, cycloalkyl, heterocyclyl, benzyl, phenyl, napthyl, heteroaryl, heteroaryl-C1-6 alkyl, or R2 and R3 together with the nitrogen to which they are bound form a 5 or 6 membered heterocyclic ring or a 5 to 7 membered heteroaryl ring, both rings optionally containing 1 or 2 additional oxygen, sulfur, S(O)m, or nitrogen atoms, said additional nitrogen atom being optionally substituted by a C1-6 alkyl or aryl group;
• m is 0, 1, or 2;
• R4 and R5 are independently hydrogen or C1-6 alkyl;
• and
• wherein any of said C1-6 alkyl, C1-6 alkenyl, C1-6 alkyl-C1-6 alkoxy, cycloalkyl, heterocyclyl, benzyl, phenyl, nalthyl, heteroaryl and heteroaryl-C1-6 alkyl groups can be optionally substituted with up to three members selected from a group consisting of halogen, hydroxyl, CF3 and N(CH3)2.