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US 2003/0195181 A1Published application
Laulimalide derivatives
AssigneeKosan Biosciences, Inc.
InventorsGary Ashley, Brian Metcalf
Life of this patent
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Abstract
Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. 1
Claims19
A compound of formula
- 47
- wherein:
- X is O or NH;
- Z is O, CH2, or a bond;
- R1 is H, OH, or C1-C5 alkoxy;
- R2 is H, OH, or C1-C5 alkoxy;
- and
- R3 is cyclohexyl, substituted cyclohexyl, 3-cyclohexenyl, substituted 3-cyclohexenyl, phenyl, substituted phenyl, pyridyl, substituted pyridyl, thiazolyl, substituted thiazolyl, or a group of the formula
- 48
- with the proviso that when Z is O that R2 is not OH.
7 more elements
Dependencies are inferred from the claim text.