Aqueous suspension preparations
OwnerShirou Sawainventor
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Abstract
Addition of polyvinylpyrrolidone and a water-soluble anionic macromolecular compound to an aqueous suspension of a hardly soluble drug allows to provide an aqueous suspension in which aggregation of drug particles, formation of macro crystals from suspended particles and formation of secondary particles from deposited particles are prevented, and adhesion and adsorption to containers made of plastics, e.g., polypropylene or polyethylene, are avoided. As it has a good redispersibility, the aqueous suspension is useful as eye drops, nasal drops, ear drops, injections, oral preparations, liniments and lotions.
Claims29
An aqueous suspension comprising a hardly soluble drug, polyvinylpyrrolidone and a water-soluble anionic macromolecular compound.
An aqueous suspension comprising a steroidal antiinflammatory drug, polyvinylpyrrolidone and alginic acid or a salt thereof.
An aqueous suspension comprising an anti-cataract drug, polyvinylpyrrolidone and alginic acid or a salt thereof.
An aqueous suspension comprising an antiphlogistic-analgesic, polyvinylpyrrolidone and alginic acid or a salt thereof.
A method for improving the redispersibility of an aqueous suspension of a hardly soluble drug comprising addition of polyvinylpyrrolidone and a water-soluble anionic macromolecular compound to the aqueous suspension.
Dependencies are inferred from the claim text.