US 2003/0195176 A1 · Vitamin d derivatives

Abstract

The object of the present invention is to provide a vitamin D derivative exhibiting excellent physiological activity as medicines, in particular as therapeutic agents for skin disease including psoriasis, and having decreased hypercalcemic activity. The present invention provides vitamin D derivatives represented by the general Formula (1): 1 wherein in Formula (1), X is oxygen or sulfur; R1 is hydrogen or Formula (2) 2 R2 is hydrogen or alkyl; R3 and R4 are hydrogen or alkyl or R3 and R4 together form a double bond between the 16- and 17-positions; R5 is hydrogen or -OR13 in which R13 is hydrogen or a protecting group; and R6 is hydrogen or a protecting group.

Claims10

Dependent claims

A vitamin D derivative of Formula (1):

14
wherein
in Formula (1), X is oxygen or sulfur;
R1 is hydrogen or Formula (2)
15
wherein
in Formula (2), A is —CO—, —CR9R10— in which R9 and R10 are hydrogen or hydroxy, —CR11=CR12— in which R11 and R12 are hydrogen or alkyl or —C≡C—;
R7 and R8 are hydrogen or hydroxy which may have a protecting group;
m is a number from 0 to 4;
and n is a number from 0 to 2;
R2 is hydrogen or alkyl;
R3 and R4 are hydrogen or alkyl or R3 and R4 together form a double bond between the 16- and 17-positions;
R5 is hydrogen or —OR13 in which R13 is hydrogen or a protecting group;
and
R6 is hydrogen or a protecting group.

12 more elements

Dependencies are inferred from the claim text.

Vitamin d derivatives

Life of this patent

Vitamin d derivatives

Life of this patent

Abstract

Claims10