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US 2003/0195169 A1Published application
Phosphate prodrugs of fluorooxindoles
AssigneeBristol-Myers Squibb Company
InventorsKevin W. Gillman, Piyasena Hewawasa, William D. Schmitz, Omar D. Lopez, John E. Starrett, David P. Provencal
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Abstract
The present invention provides novel phosphate derivatives having the general Formula I 1 wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer and A, B, R1, R2, R3, R4, m and n are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.
Claims11
A compound of the formula
- 19
- wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer;
- A is a direct bond or (C═O);
- B is a direct bond, oxygen or nitrogen;
- m is 0 or 1;
- n is 1, 2 or 3;
- R1 and R2 each are independently hydrogen or a hydrolyzable ester group;
- and when R1 is hydrogen, R2 may also be —P(O)OR5OR6 or heteroaryl;
- R3 and R4 each are independently hydrogen or C1-4 alkyl;
- and
- R5 and R6 each are independently hydrogen or a hydrolyzable ester group;
- or a nontoxic pharmaceutically acceptable salt or solvate thereof.
9 more elements
Dependencies are inferred from the claim text.