FO-6979 substances and process for producing the same
AssigneesGakkou Houjin Kitasato Gakeun, Japan Society for the Promotion of Science
InventorsSatoshi Omura, Hiroshi Tomoda
Life of this patent
Estimating the term…
Abstract
(Beauveria) sp. FO-6979 (FERM BP-6681), which belongs to the genus Beauveria and is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby accumulate the FO-6979-M0, -M1, -M2, -M3 and -M4 substances in the liquid culture medium. Then the FO-6979-M0, -M1, -M2, -M3 and -M4 substances are collected from the culture medium. The substances thus obtained are less toxic, specifically inhibit acyl-Coenzyme A: cholesterol acyltransferase, and inhibit the formation of oil droplets in macrophages. Owing to these characteristics, the above substances are useful in preventing and treating human diseases caused by cholesterol accumulation.
Claims40
FO-6979-M0 substance which is a compound represented by the following formula [I]
- 11
A process for production of novel FO-6979-M0 substance comprising culturing a microorganism to genus Beauveria and having ability to produce FO-6979-M0 substance in a medium, accumulating FO-6979-M0 substance in the cultured liquid medium and isolating FO-6979-M0 substance from said cultured mass.
A microorganism belonging to genus Beauveria and having ability to produce FO-6979-M0 substance.
A FO-6979-M1 substance which is a compound represented by the following formula [II]
- 12
A process for production of novel FO-6979-M1 substance comprising culturing a microorganism belonging to geneus Beauveria and having ability to produce FO-6979-M1 substance in a medium, accumulating FO-6979-M1 substance in the cultured liquid medium and isolating FO-6979-M1substance from said cultured mass.
A microorganism belonging to genus Beauveria and having ability to produce FO-6979-M1 substance.
FO-6979-M2 substance which is a compound represented by the following formula [III]
- 13
A process for production of novel FO-6979-M2 substance comprising culturing a microorganism belonging to genus Beauveria and having ability to produce FO-6979-M2 substance in a medium, accumulating FO-6979-M2 substance in the cultured liquid medium and isolating FO-6979-M2 substance from said cultured mass.
A microorganism belonging to genus Beauveria and having ability to produce FO-6979-M2 substance.
FO-6979-M3 substance which is a compound represented by the following formula [IV]
- 14
A process for production of novel FO-6979-M3 substance comprising culturing a microorganism belonging to genus Beauveria and having ability to produce FO-6979-M3 substance in a medium, accumulating FO-6979-M3 substance in the cultured liquid medium and isolating FO-6979-M3 substance from said cultured mass.
A microorganism belonging to genus Beauveria and having ability to produce FO-6979 M3 substance.
FO-6979-M4 substance which is a compound represented by the following formula [V]
- 15
A process for production of novel FO-6979-M4 substance comprising culturing a microorganism belonging to genus Beauveria and having ability to produce FO-6979-M4 substance in a medium, accumulating FO-6979-M4 substance in the cultured liquid medium and isolating FO-6979-M4 substance from said cultured mass.
A microorganism belonging to genus Beauveria and having ability to produce FO-6979-M4 substance.
Dependencies are inferred from the claim text.