Medicament containing a tissue inhibitor of metalloproteinases-2 (timp-2) as an osteoanabolically active substance
AssigneeIPF PharmaCeuticals GmbH
InventorsFranz-Josef Kramer, Silke Mark, Ludger Standker, Wolf-Georg Forssmann
Life of this patent
Estimating the term…
Abstract
The invention relates to TIMP-2) as an osteoanabolically active peptide for use as a medicament for treating bone defects, bone diseases and for improving bone regeneration.
Claims10
A medicament containing TIMP-2 having the amino acid sequence
- 14 Z1CSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQ IKMFKGPX1KDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHIT LCDFIVPWDTLX2TTQKKSLNHRYQNGCECKITRCPMIPCYISSRDECLW MDWVTEKX3INGHQAKFFACIKRSDGSCAWYRGAAPP KQEFLDIED P-Z2
- 15 wherein X1 represents the amino acid E or D;
- X2 represents the amino acid T or I;
- X3 represents the amino acid N or S;
- Z1 represents —NH2, a substituted amine or an arbitrary peptide having up to ten amino acids;
- Z2 represents —COOH, CONH2, a substituted amide or an arbitrary peptide having up to ten amino acids;
- and its biologically active fragments and/or amidated, acylated, sulfated, phosphorylated, glycosylated and/or polyethylene-glycol modified derivatives.
Use of TIMP-2 having the amino acid sequence
- 16 Z1CSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIK QIKMFKGPX1KDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHI TLCDFIVPWDTLX2TTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLW MDWVTEKX3TNGHQAKFFACIKRSDGSCAWYRGAAPP KQEFLDIEDP-Z2
- 17 wherein X1 represents the amino acid E or D;
- X2 represents the amino acid T or I;
- X3 represents the amino acid N or S;
- Z1 represents —NH2, a substituted amine or an arbitrary peptide having up to ten amino acids;
- Z2 represents —COOH, CONH2, a substituted amide or an arbitrary peptide having up to ten amino acids;
- and its biologically active fragments and/or amidated, acylated, sulfated, phosphorylated, glycosylated and/or polyethylene-glycol modified derivatives for preparing an osteoanabolic medicament.
Use of low-molecular weight substances and active compounds which have effects on bone cells comparable to those of TIMP-2 for preparing a medicament for treating diseases of the bone system, such as fractures, osteopenia and osteoporosis.
Use of a receptor for TIMP-2 on bone cells in connection with its related agonists and antagonists for preparing a medicament for treating diseases of the bone system, such as fractures, osteopenia and osteoporosis.
A diagnostic agent for functional disorders of the bone, containing TIMP-2 having the amino acid sequence
- 18 Z1CSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIK QIKMFKGPx1KDIEFIYTAPSSAVCGSLDVGGKKEYLIAGKAEGDGKMHIT LCDFIVPWDTLX2TTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWM DWVTEKX3INGHQAKFFACIKRSDGSCAWYRGAAPP KQEFLDIED P-Z2
- 19 wherein X1 represents the amino acid E or D;
- X2 represents the amino acid T or I;
- X3 represents the amino acid N or S;
- Z1 represents —NH2, a substituted amine or an arbitrary peptide having up to ten amino acids;
- Z2 represents —COOH, CONH2, a substituted amide or an arbitrary peptide having up to ten amino acids;
- and its biologically active fragments and/or amidated, acylated, sulfated, phosphorylated, glycosylated and/or polyethylene-glycol modified derivatives.
Use of TIMP-2 having the amino acid sequence
- 20 Z1CSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIK QTKMFKGPX1KDIEFIYTAPSSAVCGSLDVGGKKEYLIAGKAEGDGKMHIT LCDFIVPWDTLX2TTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWM DWVTEKX3INGHQAKFFACIKRSDGSCAWYRGAAPP KQEFLDIED P-Z2
- 21 wherein X1 represents the amino acid E or D;
- X2 represents the amino acid T or I;
- X3 represents the amino acid N or S;
- Z1 represents —NH2, a substituted amine or an arbitrary peptide having up to ten amino acids;
- Z2 represents —COOH, CONH2, a substituted amide or an arbitrary peptide having up to ten amino acids;
- and its biologically active fragments and/or amidated, acylated, sulfated, phosphorylated, glycosylated and/or polyethylene-glycol modified derivatives .as a diagnostic agent in functional disorders of the bone.
Dependencies are inferred from the claim text.