Anti-inflammatory peptides
AssigneeSalpep Biotechnology, Inc.
InventorRonald Mathison
Life of this patent
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Abstract
Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1—X2—X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid; 2-amino-heptanoic acid; 2-amino-octanoic acid; cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine; X2 is an acidic amino acid; and X3 is an aliphatic amino acid; or of a peptide of the formula: X4—X5 wherein X4 is an aromatic or aliphatic amino acid; and X5 is an acidic amino acid.
Claims37
A method of inhibiting an inflammatory reaction in a mammal comprising administering to the mammal an effective amount of a peptide of the formula:
- X1—X2—X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid;
- 2-amino-heptanoic acid;
- 2-amino-octanoic acid;
- cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine;
- X2 is an acidic amino acid;
- and
- X3 is an aliphatic amino acid;
- or of a peptide of the formula:
- X4 —X5 wherein X4 is an aromatic or aliphatic amino acid;
- and
- X5 is an acidic amino acid.
A method of treating asthma in a mammal comprising administering to the mammal an effective amount of a peptide of the formula:
- X1—X2—X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid;
- 2-amino-heptanoic acid;
- 2-amino-octanoic acid;
- cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine;
- X2 is an acidic amino acid;
- and
- X3 is an aliphatic amino acid;
- or of a peptide of the formula:
- X4 —X5 wherein X4 is an aromatic or aliphatic amino acid;
- and
- X5 is an acidic amino acid.
A peptide of the formula:
- X1—X2—X3 wherein
- X1—X2—X3 wherein X1 is selected from the group consisting of 2-amino-hexanoic acid;
- 2-amino-heptanoic acid;
- 2-amino-octanoic acid;
- cyclohexyl-substituted 2-amino-ethanoic acid, 2-amino-propanoic acid or 2-amino-butanoic acid and methionine;
- X2 is an acidic amino acid;
- and
- X3 is an aliphatic amino acid.
A peptide of the formula:
- X4—X5 wherein X4 is an aromatic or aliphatic amino acid;
- and
- X5 is an acidic amino acid.
Dependencies are inferred from the claim text.