Synthesis and use of anti-reverse mRBA cap analogues

A composition comprising

• 10
• wherein:
• X is selected from the group consisting of H, OH, OCH3, and OCH2CH3;
• Y is selected from the group consisting of H, OH, OCH3, and OCH2CH3;
• n is 1, 2, 3, 4, or 5;
• and
• B is selected from the group consisting of
• 11

A composition comprising

• 13
• wherein:
• X is selected from the group consisting of H, OH, OCH3, and OCH2CH3;
• Y is selected from the group consisting of H, OH, OCH3, and OCH2CH3;
• n is 1, 2, 3, 4, or 5;
• and Z is selected from the group consisting of C1 to C4 substituted or unsubstituted alkyl, C6 to C8 substituted or unsubstituted aryl, or C1 to C4 substituted or unsubstituted alkoxy;
• and wherein, if Z is CH3 and Y is OH and n is 1, then X is neither H nor OH.

A composition comprising

• 14
• wherein:
• X is selected from the group consisting of H, OH, OCH3, and OCH2CH3;
• Y is selected from the group consisting of H, OH, OCH3, and OCH2CH3;
• R is selected from the group consisting of H, CH3, CH2C6H5, CH2COC6H5, CH2CH2CH2OH, CH2CH═CH2, C1 to C4 substituted or unsubstituted alkyl, and C6 to C8 substituted or unsubstituted aryl;
• n is 1, 2, 3, 4, or 5;
• Z is selected from the group consisting of C1 to C4 substituted or unsubstituted alkyl C6 to C8 substituted or unsubstituted aryl, or C1 to C4 substituted or unsubstituted alkoxy;
• and
• B is selected from the group consisting of guanine, adenine, uridine, and cytosine;
• and wherein, if Z is CH3, and R is H, and Y is OH, and n is 1, and B is guanine;
• then X is neither H nor OH.