Method for the diagnosis and prognosis of malignant diseases
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsDonald M. Miller, Paula J. Bates, John O. Trent, Xiaohua Xu
Life of this patent
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Abstract
Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.
Claims40
A method of determining a neoplastic state of a cell, comprising:
- detecting the presence of plasma membrane nucleolin in the cell.
A method of determining a neoplastic state of a cell, comprising quantifying the amount of plasma membrane nucleolin in the cell.
A kit for determining a neoplastic state of a cell, comprising:
- an anti-nucleolin agent and
- a control sample.
31 The kit of claim 25, further comprising at least one member selected from the group consisting of a fixative, a buffer, plasticware, serum, serum albumin, non-fat milk, membranes and instructions.
A method of detecting small lung cell carcinoma in a subject, comprising:
- collecting a sample from the subject containing lung cells;
- and
- detecting the presence of nucleolin on the surface of the cells.
The method of claim 38, wherein the subject is human.
The method of claim 39, wherein the sample is sputum.
Dependencies are inferred from the claim text.