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US 2003/0194752 A1Published application
Early detection of sepsis
AssigneeBecton, Dickinson and Company
InventorsStephen J. Anderson, Douglas J. Haney, Cory A. Waters
Life of this patent
Estimating the term…
Abstract
Diagnostic methods, systems, and kits for identifying patients with systemic inflammatory response syndrome who are likely to progress to sepsis.
Claims60
A method of detecting early sepsis in a patient, wherein said method comprising the steps of:
- a) monitoring a plurality of biological markers over a period of time,
- b) independently deriving for each marker a marker statistic that is a statistical measure of extreme value of said marker over said period of time, and
- c) applying a decision rule to the marker statistics from step (b) to detect early sepsis in said patient.
A method of detecting early sepsis in a patient, wherein said method comprising the steps of:
- a) monitoring expression of markers comprising neutrophil-associated CD11b, neutrophil-associated CD64, and monocyte-associated HLA-DR over a period of time;
- b) independently deriving marker statistics comprising a maximum of said neutrophil-associated CD11b expression, a maximum of said neutrophil-associated CD64 expression, and minimum of said monocyte-associated HLA-DR expression;
- and
- c) applying a decision rule to the marker statistics from step (b) to detect early sepsis in said patient.
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Dependencies are inferred from the claim text.