Antisense oligonucleotide compositions and methods for the modulation of activating protein 1

An oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Fos protein and said oligonucleotide modulates the expression of said c-Fos protein, and wherein said oligonucleotide comprises at least one lipophilic moiety which enhances the cellular uptake of said oligonucleotide.

An oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Jun protein and said oligonucleotide modulates the expression of said c-Jun protein.

An oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Jun protein and said oligonucleotide modulates the expression of said c-Jun protein, and wherein said oligonucleotide comprises at least one lipophilic moiety which enhances the cellular uptake of said oligonucleotide.

A method of modulating the expression of a c-Fos protein in cells or tissues comprising contacting said cells or tissues with an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Fos protein and said oligonucleotide modulates the expression of said c-Fos protein.

A method of modulating the expression of a c-Jun protein in cells or tissues comprising contacting said cells or tissues with an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Jun protein and said oligonucleotide modulates the expression of said c-Jun protein.

A method of inhibiting tumor growth in an animal comprising administering to said animal a therapeutically effective amount of an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Fos protein and said oligonucleotide modulates the expression of said c-Fos protein.

A method of inhibiting tumor growth in an animal comprising administering to said animal a therapeutically effective amount of an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Jun protein and said oligonucleotide modulates the expression of said c-Jun protein.

A method of inhibiting tumor growth in an animal comprising administering to said animal a therapeutically effective amount of an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide modulates the expression of one or more matrix metalloproteinases.

A method of modulating cell cycle progression in cultured cells or the cells of an animal comprising administering to said cells an effective amount of an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Fos protein and said oligonucleotide modulates the expression of said c-Fos protein.

A method of modulating cell cycle progression in cultured cells or the cells of an animal comprising administering to said cells an effective amount of an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Jun protein and said oligonucleotide modulates the expression of said c-Jun protein.

A method of treating an animal having, suspected of having or prone to having a hyperproliferative disease comprising administering to said animal a therapeutically effective amount of a pharmaceutical composition comprising an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Fos protein and said oligonucleotide modulates the expression of said c-Fos protein and a pharmaceutically acceptable carrier.

A method of treating an animal having, suspected of having or prone to having a hyperproliferative disease comprising administering to said animal a therapeutically effective amount of a pharmaceutical composition comprising an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Jun protein and said oligonucleotide modulates the expression of said c-Jun protein and a pharmaceutically acceptable carrier.

A method of treating an animal having, suspected of having or prone to having a hyperproliferative disease comprising administering to said animal a therapeutically effective amount of a pharmaceutical composition comprising the oligonucleotide prodrug comprising an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Fos protein and said oligonucleotide modulates the expression of said c-Fos protein and a pharmaceutically acceptable carrier.

A method of treating an animal having, suspected of having or prone to having a hyperproliferative disease comprising administering to said animal a therapeutically effective amount of a pharmaceutical composition comprising the oligonucleotide prodrug comprising an oligonucleotide comprising 8 to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence specifically hybridizable with a nucleic acid encoding a c-Fos protein and said oligonucleotide modulates the expression of said c-Fos protein and a pharmaceutically acceptable carrier.