Selection of markers
OwnerTim Jatkoeinventor
Life of this patent
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Abstract
Methods of selecting a portfolio of markers for use in a diagnostic applications include defining diagnostic parameters, establishing a relationship among the parameters so that they are optimized, and selecting an optimal group of markers for the diagnostic application. The diagnostic parameters can include a measure of the relative degree of expression of a gene, a measure of the variation in the measurement of the degree of expression of the gene, and the relationship between the diagnostic and discriminating parameters can be a mean variance relationship. Machines programmed to conduct the method and articles that comprise instructions for their operation are further aspects of the invention.
Claims25
A method of selecting a portfolio of markers for use in a diagnostic application comprising:
- a) definining diagnostic parameters,
- b) establishing a relationship among the diagnostic parameters that identifies an optimized portfolio of markers,
- c) and selecting said portfolio.
A machine comprising a general purpose computer programmed to identify a portfolio of markers wherein said machine comprises instructions to employ a relationship among diagnostic parameters so that markers are optimized.
An article comprising instructions for selecting a portfolio of markers for use in a diagnostic application comprising:
- a) instructions for inputting diagnostic parameters into an algorithm,
- b) instructions for operating said algorithm wherein said algorithm relates the diagnostic parameters such that an optimized portfolio of markers is identifiable, and
- c) instructions for selecting said portfolio.
Dependencies are inferred from the claim text.