Human ion channels
OwnerSteven L. Roberds, Christopher W. Benjamin +2inventors
InventorsSteven L. Roberds, Christopher W. Benjamin, Alla M. Karnovsky, Cara L. Ruble
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Abstract
The present invention provides novel ion channel polypeptides and polynucleotides which identify and encode them. In addition, the invention provides expression vectors, host cells and methods for their production. The invention also provides methods for the identification of ion channel agonists/antagonists, useful for the treatment of human diseases and conditions.
Claims49
An isolated nucleic acid molecule comprising a nucleotide sequence that encodes a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 121, 132, and fragments thereof comprising an epitope specific to said polypeptide.
An isolated nucleic acid molecule comprising at least 10 nucleotides, said nucleic acid molecule comprising a nucleotide sequence complementary to a sequence selected from the group consisting of SEQ ID NOs:
- 120, 131, 135, 136, and fragments thereof encoding a polypeptide-specific epitope.
An isolated polypeptide wherein said polypeptide comprises a sequence selected from the group consisting of SEQ ID NOs:
- 121, 132, and fragments thereof comprising a polypeptide-specific epitope.
A method for identifying a compound useful as a modulator of binding between a polypeptide having an amino acid sequence selected from SEQ ID NOs:
- 121 and 132 and a binding partner of said polypeptide comprising the steps of:
- (a) contacting the binding partner and a composition comprising said polypeptide in the presence and in the absence of a putative modulator compound;
- and
- (b) detecting binding between the binding partner and said polypeptide, wherein decreased or increased binding between the binding partner and said polypeptide in the presence of the putative modulator, as compared to binding in the absence of the putative modulator, is indicative of a modulator compound useful for the treatment of a disorder.
Dependencies are inferred from the claim text.