Method for making a molecularly smooth surface
AssigneeGeneOhm Sciences, Inc.
InventorXing Yang
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Abstract
A method is provided for making a molecularly smooth surface, preferably on an electrode of an assay chip. This is desirable because it allows molecules, preferably oligonucloetides, to attach to the electrode surface with greater reliability and packing density than was previously available. Such attachment of molecules to an electrode surface is of particular interest in the field of electrochemical genetic analysis.
Claims32
A method for making a substantially molecularly smooth attachment surface, comprising the steps of:
- providing a substrate that is smooth to within about 10 atomic diameters of the substrate material;
- applying an attachment material to the smooth substrate;
- and
- etching away at least a portion of the substrate to reveal a smooth matching surface of the attachment material.
(Original) A method for making a substantially molecularly smooth attachment surface, comprising the steps of:
- providing a substrate that is smooth to within about 10 atomic diameters of the substrate material;
- applying an attachment material to the smooth substrate;
- and
- etching away at least a portion of the substrate to reveal a smooth matching surface of the attachment material.
(Original) The method of claim 1 wherein the substrate is etched away to reveal a molecularly smooth attachment surface in a plurality of locations.
- Claims 12-21 Canceled
An assay chip having a first surface and a second surface, comprising:
- a substrate layer having a first surface and a second surface corresponding respectively in location to the first surface and second surface of the assay chip, wherein the second surface of the substrate is smooth to within 10 atomic diameters of the substrate;
- at least one conductor deposited on the second surface of the substrate;
- an assay region accessible from the first surface of the substrate, in which the substrate has been etched away to expose a portion of conductor;
- and
- one or more assay reagents attached to the conductor in the assay region.
Dependencies are inferred from the claim text.