Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
OwnerSharron Gaynor Penn, David Russell Rank +1inventors
InventorsSharron Gaynor Penn, David Russell Rank, David Kagen Hanzel
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Abstract
Methods and apparatus for predicting, confirming and displaying functional regions from genomic sequence data are used to identify 13,700 unique human genome-derived single exon probes useful for gene expression analysis, particularly gene expression analysis by microarray. Also presented are genome-derived single exon microarrays that include such probes, peptides encoded by the exons, and antibodies thereto.
Claims53
A nucleic acid probe for measuring human gene expression, comprising:
- a nucleotide sequence as set forth in any one of SEQ ID NOs:
- 13,701-27,400, the complement thereof, or a fragment of said SEQ ID NO:
- or said complement,
- wherein said probe is a single exon probe that hybridizes under high stringency conditions to a nucleic acid molecule expressed in human cells or tissues.
A nucleic acid probe for measuring human gene expression, comprising:
- a nucleotide sequence that encodes, or the complement of which encodes, at least 8 amino acids of any one of SEQ ID NOs:
- 27,401-34,288,
- wherein said probe is a single exon probe that hybridizes under high stringency conditions to a nucleic acid molecule expressed in human cells or tissues.
An ORF-encoded peptide, comprising:
- at least 8 contiguous amino acids of any one of SEQ ID NOs:
- 27,401-34,288 or at least 8 contiguous amino acids of any one of SEQ ID NOs:
- 27,401-34,288 with conservative amino acid substitutions.
A computer readable storage medium storing instructions that, when executed by a computer, causes the computer to perform the method of any one of claims 48 to 51.
Dependencies are inferred from the claim text.