Association of thrombospondin polymorphisms with vascular disease
OwnerStacey Bolk, George Q. Daley +1inventors
InventorsStacey Bolk, George Q. Daley, Jeanette J. McCarthy
Life of this patent
Estimating the term…
Abstract
A role for the thrombospondin gene(s), particularly TSP-2, in vascular disease is disclosed. Use of single nucleotide polymorphisms in the thrombospondin gene(s) for diagnosis, prediction of clinical course and treatment response, development of therapeutics and development of cell-culture-based and animal models for research and treatment are disclosed.
Claims21
A method of predicting the likelihood of a vascular disease in an individual, comprising:
- a) obtaining a nucleic acid sample from the individual;
- and
- b) determining the genotype of the individual at nucleotide position 3949 of the thrombospondin-2 gene,
- wherein an individual who is homozygous for the variant allele has a decreased likelihood of a vascular disease as compared with an individual who is heterozygous or homozygous for the reference allele.
A method of predicting the likelihood of a vascular disease in an individual, comprising:
- a) obtaining a nucleic acid sample from the individual;
- and
- b) determining the genotype of the individual at nucleotide position 3949 of the thrombospondin-2 gene,
- wherein an individual who is heterozygous or homozygous for the reference allele has an increased likelihood of a vascular disease as compared with an individual who is homozygous for the variant allele.
A method of diagnosing or aiding in the diagnosis of a vascular disease in an individual, comprising:
- a) obtaining a nucleic acid sample from the individual, and b) determining the nucleotide present at nucleotide position 3949 of the thrombospondin-2 gene;
- wherein presence of a T at nucleotide 3949 is indicative of an increased likelihood of a vascular disease in the individual, as compared with an individual having G at position 3949.
A method of diagnosing or aiding in the diagnosis of a vascular disease in an individual, comprising:
- a) obtaining a nucleic acid sample from the individual;
- and
- b) determining the genotype of the individual at nucleotide position 3949 of the thrombospondin-2 gene,
- wherein an individual who is homozygous for the variant allele has a decreased likelihood of a vascular disease as compared with an individual who is heterozygous or homozygous for the reference allele.
A nucleic acid molecule comprising all or a portion of the nucleic acid sequence of SEQ ID NO:
- 1 wherein said nucleic acid molecule is at least 10 nucleotides in length and wherein the nucleic acid sequence comprises a polymorphic site at nucleotide position 3949 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.