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AssigneeLupin Limited
InventorsSudershan Kumar Arora, Lavleen Kumar Gupta, Vandita Srivastava, Narender Sanganabhatla, Dinesh Balakrishna Saraf
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The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum, which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, MEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.
A herbal composition, for oral administration and topical application for the treatment of psoriasis and related biochemical and immunological disorders, comprising an effective amount of, an extract of the leaves and/or stem of Argemone mexicana plant, containing organic constituents, in combination with pharmaceutically acceptable carriers, the said extract exhibiting interesting immunological and pharmacological properties.
A herbal composition, for oral administration for the treatment of psoriasis and related biochemical and immunological disorders comprising an effective amount of an extract of the leaves and/or stem of Argemone mexicana plant, containing organic constituents, and an extract of the fruits of Cuminum cyminum plant in combination with pharmaceutically acceptable carriers, the said extract exhibiting interesting immunological and pharmacological properties
A herbal composition, for oral administration and topical application for the treatment of psoriasis and related biochemical and immunological disorders, comprising an effective amount of, a fraction, containing organic constituents, obtained from the leaves and/or stem of Argemone mexicana plant, in combination with pharmaceutically acceptable carriers, the said fraction exhibiting interesting immunological and pharmacological properties.
52 The herbal composition according to claim 35, suitable for topical application, in the from of ointments, creams, gels, lotions, oils, or transdermal drug delivery systems.
53 The herbal composition according to claim 1 wherein said pharmaceutically acceptable carriers are selected from sugars such as lactose, sucrose, mannitol, sorbitol and xylitol;
54 The herbal composition according to claim 2 wherein said pharmaceutically acceptable carriers are selected from sugars such as lactose, sucrose, mannitol, sorbitol and xylitol;
55 The process for preparation of an extract of the leaves and/or stem of Argemone mexicana plant of any one of claims 1 and 2, comprising the steps of,
A process according to claim 55, wherein the solvent is selected from water, ethanol or mixtures thereof.
A process according to claim 55, wherein the solvent is evaporated in a rotary evaporator at a temperature below 50° C.
A process according to claim 55, wherein the organic constituents extracted include alkaloids, flavonoids, amino acids, organic acids, sugars/glycosides and salts.
A process according to claim 55, wherein the base number of the extract of the leaves and/or stem of Argemone mexicana plant is from 280 to 345.
A process for preparation of the methanol-insoluble fraction of the leaves and/or stem of Argemone mexicana plant according to claims 39 comprising the steps of,
Dependencies are inferred from the claim text.