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US 2003/0194448 A1Published application
Oral rehydration composition
AssigneeNone recorded
InventorsCheryl R. Mitchell, Charlene B. Riikonene, David A. Sack
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AssigneeNone recorded
InventorsCheryl R. Mitchell, Charlene B. Riikonene, David A. Sack
Estimating the term…
A rehydration composition and oral delivery system is provided that allows for enhanced functional ingredient delivery when ingested orally as a water based solution. The rehydration composition comprises a low fiber colloidal hydrolyzed rice carbohydrate ingredient having, on a dry weight basis, less than 0.1% fiber and between 0.5% and 1.0% protein and between 0-0.5% and 1.0% fat, and having a dextrose equivalency (DE) value within the approximate range of 20-30 (commonly DE 25), and electrolytes such as sodium, potassium, citrate, and/or bicarbonate. The rehydration composition, which is concentrated or dried, becomes an oral rehydration solution (ORS) when mixed with water for oral consumption. The rehydration composition, when mixed with active ingredients such as vaccines, drugs, amino acids, mineral salts, vitamins, nutraceuticals, probiotics, prebiotics, flavors, or nutritive or non-nutritive sweeteners, is referred to as an oral delivery system. This oral delivery system may then be further diluted in a water base to produce an oral delivery solution that is suitable for oral ingestion by a user.
An oral rehydration composition, comprising an effective amount of electrolytes and carbohydrates that are suitable for dissolving in a water base so as to produce an oral rehydration solution having an osmolality of less than 400 milliosmoles;
12 The oral rehydration composition according to claim 10 concentrated to a syrup of between 78 and 85 Brix.
13 The oral dehydration composition according to claim 5 further comprising at least one of at least one nutraceutical or at least one functional ingredient.
14 The oral rehydration composition according to claim 15 further comprising water.
15 The oral rehydration composition according to claim 16 comprising less than 5% water.
16 The oral rehydration composition according to claim 16 concentrated to a syrup of between 78 and 85 Brix.
17 The oral rehydration compositions according to claim 1 further comprising an additional flavor component.
18 The oral rehydration compositions according to claim 5 further comprising an additional flavor component.
19 The oral rehydration compositions according to claim 9 further comprising an additional flavor component.
20 The oral rehydration compositions according to claim 1 further comprising an additional acid component for the purpose of pH adjustment.
21 The oral rehydration compositions according to claim 5 further comprising an additional acid component for the purpose of pH adjustment.
22 The oral rehydration compositions according to claim 9 further comprising an additional acid component for the purpose of pH adjustment.
Dependencies are inferred from the claim text.
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Medicinal preparations containing inorganic active ingredients: alkali metal chlorides; Alkaline earth metal chlorides
Foods or foodstuffs containing additives ; Preparation or treatment thereof: containing carbohydrate syrups; containing sugars; containing sugar…
Using additives: inorganic salts, minerals or trace elements
Medicinal preparations containing organic active ingredients: carbohydrates; Sugars; Derivatives thereof
Term end not estimated
The present invention relates to the field of rehydration compositions. More specifically, the present invention relates to dried, or dehydrated, rehydration compositions comprising, at the least, a low fiber, colloidal, hydrolyzed ,rice based carbohydrate ingredient.
Historically, in cases of dehydration caused by excessive sweating or illness resulting in body fluid loss, replenishment of lost body fluids by water is essential. While water is an essential component in fluid replacement, it is also recognized that certain salts containing ions (electrolytes) such as sodium, potassium, and citrate must be replaced along with the water. In general, aqueous solutions containing just these salts are not well absorbed by the body and are not organoleptically acceptable. That is, most people find aqueous salt solutions very difficult to consume.
More recently, it was discovered that carbohydrates, more specifically glucose, promote the absorption of these ions as well as providing sufficient sweetness to promote organoleptic acceptability of the product. During the last forty years, the World Health Organization has promoted an oral rehydration composition that utilizes glucose in combination with electrolytes. This composition, when dissolved in water, produces an oral rehydration solution “ORS”, which has had a significant impact on the survival rate of cholera victims. It is known that different carbohydrate sources have been utilized in an effort to improve the absorption of the electrolytes.
Below are illustrative formulations of the composition according to the present invention. 1 Ingredient Grams/Liter Formula 1 Water 953.400 Rice Syrup Solids, 30 DE 40.000 Sucrose 20.300 Sodium Chloride 0.800 Potassium Chloride 0.300 Trisodium Citrate 0.600 Lemon Flavor 0.600 TOTAL 1,016.000 Osmolarily: 210 mmol/kg Formula 2 Water 956.445 Rice Syrup Solids, 20 DE 50.000 Sucralose 0.035 Sodium Chloride 0.800 Potassium Chloride 0.400 Citric Acid 1.300 Trisodium Citrate 0.600 Mixed Berry Flavor 0.400 FD&C Red No. 40 0.020 TOTAL 1,010.000 Osmolarity: 170 mmol/kg Formula 3 Water 956.350 Rice Syrup Solids, 25 DE 40.000 Sucrose 16.000 Sodium Chloride 1.150 Potassium Chloride 1.500 Trisodium Citrate 3.000 Inulin 2.000 Lactobacillus reuteri* 5 × 108 CFU *In dry mix form only TOTAL 1,020.000 Osmolarity: 290 mmol/kg Formula 4 Water 965.965 Rice Syrup Solids, 25 DE 45.000 Sucralose 0.035 Sodium Chloride 2.300 Potassium Chloride 1.500 Trisodium Citrate 2.900 Orange Flavor 1.000 Citric Acid 1.300 TOTAL 1,020.000 Osmolarity: 290 mmol/kg Formula 5 Water 965.384 Rice Syrup Solids, 20 DE 40.000 Sodium Chloride 2.300 Potassium Chloride 1.500 Magnesium Chloride 1.570 Trisodium Citrate 2.900 Chicken Broth Flavoring 1.200 Histidine 0.146 TOTAL 1,015.000 Osmolarity: 290 mmol/kg Formula 6 Water 950.449 Rice Syrup Solids, 30 DE 45.000 Sucralose 0.050 Sodium Bicarbonate 10.000 Trisodium Citrate 2.500 Mango Flavor 2.000 DukoralTM Killed Cholera 0.001 Vaccine* *One dose consists of 1011 killed bacteria in 1 milligram of Cholera B subunit. TOTAL 1,010.000 Osmolarity: 375 mmol/kg
The first illustrative formula utilizes rice syrup solids with a DE of 30, sucrose as a sweetener, sodium chloride and potassium chloride for electrolytes, and trisodium citrate and lemon flavor for flavoring elements. This formulation provide a solution with a total osmolarity of 210 mmol/kg, well under the 400 mmol/kg that causes adverse physiological effects.
The second illustrative formulation utilizes rice syrup solids with a DE of 20, sucralose as a sweetener, sodium chloride and potassium chloride for electrolytes, citric acid, trisodium citrate and mixed berry flavor for flavoring elements and finally, FD&C Red No. 40 for a coloring element. This formulation provides a solution having an osmolarity of 170 mmol/kg.