Replikin peptides and antibodies therefore
AssigneeNone recorded
InventorsSamuel Bogoch, Elenore S. Bogoch
Life of this patent
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Abstract
The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
Drawings
Claims173
An isolated or synthesized peptide comprising from 7 to about 50 amino acids comprising:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized viral peptide comprising from 7 to about 50 amino acids comprising:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
11 The peptide of claim 4 wherein said viral peptide is a meleagrid herpes virus peptide.
An isolated bacterial peptide comprising from 7 to about 50 amino acids including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized fungal peptide comprising from 7 to about 50 amino acids comprising:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized algal peptide comprising from 7 to about 50 amino acids comprising:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized yeast peptide comprising from 7 to about 50 amino acids including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized amoeba peptide comprising from 7 to about 50 amino acids comprising:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and (3) at least 6% lysine residues.
An isolated or synthesized plant peptide comprising from 7 to about 50 amino acids comprising:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized structural replication-associated peptide comprising from 7 to about 50 amino acids comprising:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized tumor virus associated peptide comprising from 7 to about 50 amino acids including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An isolated or synthesized transforming-associated peptide comprising from 7 to about 50 amino acids including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues. transforming-associated peptide.
A method for increasing the replication rate of an organism comprising transforming a gene encoding an enzyme or other protein having a replication function in the organism with at least one Replikin structure.
An antibody that specifically binds to a viral peptide sequence having from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody that specifically binds to a bacterial peptide sequence having from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody that specifically binds to a fungal peptide sequence having from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody that specifically binds to a yeast peptide or polypeptide sequence comprising from 7 to about 50 amino acids including:
- (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody that specifically binds to an amoeba peptide or polypeptide sequence comprising from 7 to about 50 amino acids including:
- (1) at least one lysine residue located six to ten amino acid residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody cocktail comprising a plurality of antibodies, wherein each of the antibodies specifically binds to a viral peptide sequence comprising from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody cocktail comprising a plurality of antibodies, wherein each of the antibodies specifically binds to a bacterial peptide sequence comprising from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody cocktail comprising a plurality of antibodies, wherein each of the antibodies specifically binds to a fungal peptide sequence comprising from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody cocktail comprising a plurality of antibodies, wherein each of the antibodies specifically binds to a yeast peptide sequence comprising from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
An antibody cocktail comprising a plurality of antibodies, wherein each of the antibodies specifically binds to a amoeba peptide sequence comprising from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine residue;
- (2) at least one histidine residue;
- and
- (3) at least 6% lysine residues.
A process for stimulating the immune system of a subject to produce antibodies that bind specifically to viral Replikins, said process comprising administering to the subject an effective amount of a dosage of a composition comprising at least one viral Replikin peptide.
A process for stimulating the immune system of a subject to produce antibodies that bind specifically to viral Replikins, said process comprising administering to the subject an effective amount of a dosage of a composition comprising at least one non-immune-based organic agent that specifically targets bacterial Replikin sequences.
A dual treatment method of treating malaria comprising:
- (1) administering an effective amount of at least one proteolytic enzyme;
- and
- (2) administering an effective amount of at least one antibody specific for at least one isolated Plasmodium falciparum Replikin peptide having from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine;
- (2) at least one histidine;
- and
- (3) at least 6% lysine residues.
A method of treating malaria comprising:
- (1) administering an effective amount of at least one proteolytic enzyme;
- and
- (2) administering an effective amount of a preventive or therapeutic vaccine comprising at least one isolated Plasmodium falciparum Replikin peptide having from 7 to about 50 amino acids and including:
- (1) at least one lysine residue located six to ten residues from a second lysine;
- (2) at least one histidine;
- and
- (3) at least 6% lysine residues.
A method to recognize a Replikin peptide structure called the “three-point recognition method” whereby the Replikin peptide is composed of from seven (7) to about (50) amino acids and include:
- (1) at least one lysine residue located six to ten residues from a second lysine;
- (2) at least one histidine;
- and
- (3) at least 6% lysine residues.
Dependencies are inferred from the claim text.