Nanoemulsion vaccines
AssigneeThe Regents of the University of Michigan
InventorsJames R. Baker, Tarek Hamouda
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Abstract
The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
Claims63
A composition comprising a vaccine, said vaccine comprising an emulsion and an immunogen, said emulsion comprising an aqueous phase, an oil phase, and a solvent.
A kit comprising a vaccine, said vaccine comprising an emulsion and an immunogen, said emulsion comprising an aqueous phase, an oil phase, and a solvent.
A method of inducing immunity to an immunogen, comprising:
- a) providing:
- (i) an emulsion comprising an aqueous phase, an oil phase, and a solvent;
- and
- (ii) an immunogen;
- b) combining said emulsion with said immunogen to generate a vaccine composition;
- and
- c) administering said vaccine composition to a subject.
Dependencies are inferred from the claim text.