US 2003/0194410 A1 · Secreted and transmembrane polypeptides and nucleic acids encoding the same

Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

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Drawings

Claims57

Dependent claims

Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence that encodes an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:

2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) and FIG. 236 (SEQ ID NO:
618).

91 more elements

Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the nucleotide sequence shown in FIG. 1 (SEQ ID NO:

1), FIG. 3 (SEQ ID NO:
6), FIG. 8 (SEQ ID NO:
18), FIG. 10 (SEQ ID NO:
27), FIG. 14 (SEQ ID NO:
35), FIG. 19 (SEQ ID NO:
44), FIG. 21 (SEQ ID NO:
51), FIG. 23 (SEQ ID NO:
58), FIG. 25 (SEQ ID NO:
63), FIG. 27 (SEQ ID NO:
68), FIG. 29 (SEQ ID NO:
73), FIG. 32 (SEQ ID NO:
84), FIG. 34 (SEQ ID NO:
89), FIG. 36 (SEQ ID NO:
96), FIG. 38 (SEQ ID NO:
101), FIG. 40 (SEQ ID NO:
108), FIG. 42 (SEQ ID NO:
113), FIG. 44 (SEQ ID NO:
118), FIG. 46 (SEQ ID NO:
123), FIG. 48 (SEQ ID NO:
131), FIG. 50 (SEQ ID NO:
136), FIG. 52 (SEQ ID NO:
144), FIG. 54 (SEQ ID NO:
149), FIG. 58 (SEQ ID NO:
156), FIG. 60 (SEQ ID NO:
161), FIG. 62 (SEQ ID NO:
168), FIG. 65 (SEQ ID NO:
177), FIG. 67 (SEQ ID NO:
182), FIG. 69 (SEQ ID NO:
189), FIG. 72 (SEQ ID NO:
195), FIG. 74 (SEQ ID NO:
205), FIG. 76 (SEQ ID NO:
210), FIG. 78 (SEQ ID NO:
215), FIG. 80 (SEQ ID NO:
220), FIG. 82 (SEQ ID NO:
225), FIG. 84 (SEQ ID NO:
230), FIG. 86 (SEQ ID NO:
235), FIG. 88 (SEQ ID NO:
244), FIG. 90 (SEQ ID NO:
253), FIG. 92 (SEQ ID NO:
258), FIG. 94 (SEQ ID NO:
263), FIG. 97 (SEQ ID NO:
269), FIG. 108 (SEQ ID NO:
283), FIG. 117 (SEQ ID NO:
295), FIG. 119 (SEQ ID NO:
300), FIG. 121 (SEQ ID NO:
302), FIG. 124 (SEQ ID NO:
308), FIG. 128 (SEQ ID NO:
321), FIG. 131 (SEQ ID NO:
329), FIG. 135 (SEQ ID NO:
336), FIG. 138 (SEQ ID NO:
345), FIG. 141 (SEQ ID NO:
351), FIG. 144 (SEQ ID NO:
357), FIG. 146 (SEQ ID NO:
362), FIG. 148 (SEQ ID NO:
369), FIG. 150 (SEQ ID NO:
374), FIG. 152 (SEQ ID NO:
379), FIG. 154 (SEQ ID NO:
384), FIG. 156 (SEQ ID NO:
389), FIG. 158 (SEQ ID NO:
394), FIG. 160 (SEQ ID NO:
399), FIG. 162 (SEQ ID NO:
404), FIG. 164 (SEQ ID NO:
409), FIG. 166 (SEQ ID NO:
414), FIG. 168 (SEQ ID NO:
419), FIG. 170 (SEQ ID NO:
424), FIG. 172 (SEQ ID NO:
429), FIG. 176 (SEQ ID NO:
436), FIG. 178 (SEQ ID NO:
441), FIG. 180 (SEQ ID NO:
446), FIG. 182 (SEQ ID NO:
451), FIG. 184 (SEQ ID NO:
453), FIG. 186 (SEQ ID NO:
455), FIG. 189 (SEQ ID NO:
458), FIG. 191 (SEQ ID NO:
463), FIG. 193 (SEQ ID NO:
465), FIG. 195 (SEQ ID NO:
467), FIG. 197 (SEQ ID NO:
469), FIG. 199 (SEQ ID NO:
471), FIG. 201 (SEQ D NO:
476), FIG. 203 (SEQ ID NO:
482), FIG. 206 (SEQ ID NO:
487), FIG. 208 (SEQ ID NO:
495), FIG. 210 (SEQ ID NO:
497), FIG. 212 (SEQ ID NO:
505), FIG. 214 (SEQ ID NO:
507), FIG. 216 (SEQ ID NO:
509), FIG. 218 (SEQ ID NO:
514), FIG. 221 (SEQ ID NO:
522), FIG. 224 (SEQ ID NO:
525), FIG. 229 (SEQ ID NO:
611), FIG. 231 (SEQ ID NO:
613), FIG. 233 (SEQ ID NO:
615) and FIG. 235 (SEQ ID NO:
617).

91 more elements

Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the full-length coding sequence of the nucleotide sequence shown in FIG. 1 (SEQ ID NO:

1), FIG. 3 (SEQ ID NO:
6), FIG. 8 (SEQ ID NO:
18), FIG. 10 (SEQ ID NO:
27), FIG. 14 (SEQ ID NO:
35), FIG. 19 (SEQ ID NO:
44), FIG. 21 (SEQ ID NO:
51), FIG. 23 (SEQ ID NO:
58), FIG. 25 (SEQ ID NO:
63), FIG. 27 (SEQ ID NO:
68), FIG. 29 (SEQ ID NO:
73), FIG. 32 (SEQ ID NO:
84), FIG. 34 (SEQ ID NO:
89), FIG. 36 (SEQ ID NO:
96), FIG. 38 (SEQ ID NO:
101), FIG. 40 (SEQ ID NO:
108), FIG. 42 (SEQ ID NO:
113), FIG. 44 (SEQ ID NO:
118), FIG. 46 (SEQ ID NO:
123), FIG. 48 (SEQ ID NO:
131), FIG. 50 (SEQ ID NO:
136), FIG. 52 (SEQ ID NO:
144), FIG. 54 (SEQ ID NO:
149), FIG. 58 (SEQ ID NO:
156), FIG. 60 (SEQ ID NO:
161), FIG. 62 (SEQ ID NO:
168), FIG. 65 (SEQ ID NO:
177), FIG. 67 (SEQ ID NO:
182), FIG. 69 (SEQ ID NO:
189), FIG. 72 (SEQ ID NO:
195), FIG. 74 (SEQ ID NO:
205), FIG. 76 (SEQ ID NO:
210), FIG. 78 (SEQ ID NO:
215), FIG. 80 (SEQ ID NO:
220), FIG. 82 (SEQ ID NO:
225), FIG. 84 (SEQ ID NO:
230), FIG. 86 (SEQ ID NO:
235), FIG. 88 (SEQ ID NO:
244), FIG. 90 (SEQ ID NO:
253), FIG. 92 (SEQ ID NO:
258), FIG. 94 (SEQ ID NO:
263), FIG. 97 (SEQ ID NO:
269), FIG. 108 (SEQ ID NO:
283), FIG. 117 (SEQ ID NO:
295), FIG. 119 (SEQ ID NO:
300), FIG. 121 (SEQ ID NO:
302), FIG. 124 (SEQ ID NO:
308), FIG. 128 (SEQ ID NO:
321), FIG. 131 (SEQ ID NO:
329), FIG. 135 (SEQ ID NO:
336), FIG. 138 (SEQ ID NO:
345), FIG. 141 (SEQ ID NO:
351), FIG. 144 (SEQ ID NO:
357), FIG. 146 (SEQ ID NO:
362), FIG. 148 (SEQ ID NO:
369), FIG. 150 (SEQ ID NO:
374), FIG. 152 (SEQ ID NO:
379), FIG. 154 (SEQ ID NO:
384), FIG. 156 (SEQ ID NO:
389), FIG. 158 (SEQ ID NO:
394), FIG. 160 (SEQ ID NO:
399), FIG. 162 (SEQ ID NO:
404), FIG. 164 (SEQ ID NO:
409), FIG. 166 (SEQ ID NO:
414), FIG. 168 (SEQ ID NO:
419), FIG. 170 (SEQ ID NO:
424), FIG. 172 (SEQ ID NO:
429), FIG. 176 (SEQ ID NO:
436), FIG. 178 (SEQ ID NO:
441), FIG. 180 (SEQ ID NO:
446), FIG. 182 (SEQ ID NO:
451), FIG. 184 (SEQ ID NO:
453), FIG. 186 (SEQ ID NO:
455), FIG. 189 (SEQ ID NO:
458), FIG. 191 (SEQ ID NO:
463), FIG. 193 (SEQ ID NO:
465), FIG. 195 (SEQ ID NO:
467), FIG. 197 (SEQ ID NO:
469), FIG. 199 (SEQ ID NO:
471), FIG. 201 (SEQ ID NO:
476), FIG. 203 (SEQ ID NO:
482), FIG. 206 (SEQ ID NO:
487), FIG. 208 (SEQ ID NO:
495), FIG. 210 (SEQ ID NO:
497), FIG. 212 (SEQ ID NO:
505), FIG. 214 (SEQ ID NO:
507), FIG. 216 (SEQ ID NO:
509), FIG. 218 (SEQ ID NO:
514), FIG. 221 (SEQ ID NO:
522), FIG. 224 (SEQ ID NO:
525), FIG. 229 (SEQ ID NO:
611), FIG. 231 (SEQ ID NO:
613), FIG. 233 (SEQ ID NO:
615) and FIG. 235 (SEQ ID NO:
617).

91 more elements

An isolated polypeptide having at least 80% amino acid sequence identity to an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:

2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
4,68), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) and FIG. 236 (SEQ ID NO:
618).

91 more elements

An isolated polypeptide scoring at least 80% positives when compared to an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:

2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) and FIG. 236 (SEQ ID NO:
618).

91 more elements

Isolated nucleic acid having at least 80% nucleic acid sequence identity to:

(a) a nucleotide sequence encoding the polypeptide shown in FIG. 2 (SFQ ID NO:
2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ I D NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ I D NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) or FIG. 236 (SEQ ID NO:
618), lacking its associated signal peptide;
(b) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) or FIG. 236 (SEQ ID NO:
618), with its associated signal peptide;
or
(c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) or FIG. 236 (SEQ ID NO:
618), lacking its associated signal peptide.

283 more elements

An isolated polypeptide having at least 80% amino acid sequence identity to:

(a) the polypeptide shown in FIG. 2 (SEQ ID NO:
2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) or FIG. 236 (SEQ ID NO:
618), lacking its associated signal peptide;
(b) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) or FIG. 236 (SEQ ID NO:
618), with its associated signal peptide;
or
(c) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
2), FIG. 4 (SEQ ID NO:
7), FIG. 9 (SEQ ID NO:
19), FIG. 11 (SEQ ID NO:
28), FIG. 15 (SEQ ID NO:
36), FIG. 20 (SEQ ID NO:
45), FIG. 22 (SEQ ID NO:
52), FIG. 24 (SEQ ID NO:
59), FIG. 26 (SEQ ID NO:
64), FIG. 28 (SEQ ID NO:
69), FIG. 30 (SEQ ID NO:
74), FIG. 33 (SEQ ID NO:
85), FIG. 35 (SEQ ID NO:
90), FIG. 37 (SEQ ID NO:
97), FIG. 39 (SEQ ID NO:
102), FIG. 41 (SEQ ID NO:
109), FIG. 43 (SEQ ID NO:
114), FIG. 45 (SEQ ID NO:
119), FIG. 47 (SEQ ID NO:
124), FIG. 49 (SEQ ID NO:
132), FIG. 51 (SEQ ID NO:
137), FIG. 53 (SEQ ID NO:
145), FIG. 55 (SEQ ID NO:
150), FIG. 59 (SEQ ID NO:
157), FIG. 61 (SEQ ID NO:
162), FIG. 63 (SEQ ID NO:
169), FIG. 66 (SEQ ID NO:
178), FIG. 68 (SEQ ID NO:
183), FIG. 70 (SEQ ID NO:
190), FIG. 73 (SEQ ID NO:
196), FIG. 75 (SEQ ID NO:
206), FIG. 77 (SEQ ID NO:
211), FIG. 79 (SEQ ID NO:
216), FIG. 81 (SEQ ID NO:
221), FIG. 83 (SEQ ID NO:
226), FIG. 85 (SEQ ID NO:
231), FIG. 87 (SEQ ID NO:
236), FIG. 89 (SEQ ID NO:
245), FIG. 91 (SEQ ID NO:
254), FIG. 93 (SEQ ID NO:
259), FIG. 95 (SEQ ID NO:
264), FIG. 98 (SEQ ID NO:
270), FIG. 109 (SEQ ID NO:
284), FIG. 118 (SEQ ID NO:
296), FIG. 120 (SEQ ID NO:
301), FIG. 122 (SEQ ID NO:
303), FIG. 125 (SEQ ID NO:
309), FIG. 129 (SEQ ID NO:
322), FIG. 132 (SEQ ID NO:
330), FIG. 136 (SEQ ID NO:
337), FIG. 139 (SEQ ID NO:
346), FIG. 142 (SEQ ID NO:
352), FIG. 145 (SEQ ID NO:
358), FIG. 147 (SEQ ID NO:
363), FIG. 149 (SEQ ID NO:
370), FIG. 151 (SEQ ID NO:
375), FIG. 153 (SEQ ID NO:
380), FIG. 155 (SEQ ID NO:
385), FIG. 157 (SEQ ID NO:
390), FIG. 159 (SEQ ID NO:
395), FIG. 161 (SEQ ID NO:
400), FIG. 163 (SEQ ID NO:
405), FIG. 165 (SEQ ID NO:
410), FIG. 167 (SEQ ID NO:
415), FIG. 169 (SEQ ID NO:
420), FIG. 171 (SEQ ID NO:
425), FIG. 173 (SEQ ID NO:
430), FIG. 177 (SEQ ID NO:
437), FIG. 179 (SEQ ID NO:
442), FIG. 181 (SEQ ID NO:
447), FIG. 183 (SEQ ID NO:
452), FIG. 185 (SEQ ID NO:
454), FIG. 187 (SEQ ID NO:
456), FIG. 190 (SEQ ID NO:
459), FIG. 192 (SEQ ID NO:
464), FIG. 194 (SEQ ID NO:
466), FIG. 196 (SEQ ID NO:
468), FIG. 198 (SEQ ID NO:
470), FIG. 200 (SEQ ID NO:
472), FIG. 202 (SEQ ID NO:
477), FIG. 204 (SEQ ID NO:
483), FIG. 207 (SEQ ID NO:
488), FIG. 209 (SEQ ID NO:
496), FIG. 211 (SEQ ID NO:
498), FIG. 213 (SEQ ID NO:
506), FIG. 215 (SEQ ID NO:
508), FIG. 217 (SEQ ID NO:
510), FIG. 219 (SEQ ID NO:
515), FIG. 222 (SEQ ID NO:
523), FIG. 225 (SEQ ID NO:
526), FIG. 230 (SEQ ID NO:
612), FIG. 232 (SEQ ID NO:
614), FIG. 234 (SEQ ID NO:
616) or FIG. 236 (SEQ ID NO:
618), lacking its associated signal peptide.

283 more elements

Dependencies are inferred from the claim text.

Description176,462 words

Summary57,240 words

#The present invention relates generally to the identification and isolation of novel DNA and to the recombinant production of novel polypeptides encoded by that DNA.

#Extracellular proteins play an important role in the formation, differentiation and maintenance of multicellular organisms. The fate of many individual cells, e.g., proliferation, migration, differentiation, or interaction with other cells, is typically governed by information received from other cells and/or the immediate environment. This information is often transmitted by secreted polypeptides (for instance, mitogenic factors, survival factors, cytotoxic factors, differentiation factors, neuropeptides, and hormones) which are, in turn, received and interpreted by diverse cell receptors or membrane-bound proteins. These secreted polypeptides or signaling molecules normally pass through the cellular secretory pathway to reach their site of action in the extracellular environment.

#Secreted proteins have various industrial applications, including pharmaceuticals, diagnostics, biosensors and bioreactors. Most protein drugs available at present, such as thrombolytic agents, interferons, interleukins, erythropoietins, colony stimulating factors, and various other cytokines, are secretory proteins. Their receptors, which are membrane proteins, also have potential as therapeutic or diagnostic agents. Efforts are being undertaken by both industry and academia to identify new, native secreted proteins. Many efforts are focused on the screening of mammalian recombinant DNA libraries to identify the coding sequences for novel secreted proteins. Examples of screening methods and techniques are described in the literature [see, for example, Klein et al., Proc. Natl. Acad. Sci., 93:7108-7113 (1996); U.S. Pat. No. 5,536,637)].

Brief description of the drawings236 figures

#FIG. 1 shows a nucleotide sequence (SEQ ID NO: 1) of a native sequence PRO213 cDNA, wherein SEQ ID NO: 1 is a clone designated herein as “UNQ187” and/or “DNA30943-1163”.

#FIG. 2 shows the amino acid sequence (SEQ ID NO: 2) derived from the coding sequence of SEQ ID NO: 1 shown in FIG. 1.

#FIG. 3 shows a nucleotide sequence (SEQ ID NO: 6) of a native sequence PRO274 cDNA, wherein SEQ ID NO: 6 is a clone designated herein as “UNQ241” and/or “DNA39987-1184”.

Detailed description113,355 words

#I. Definitions

#The terms “PRO polypeptide” and “PRO” as used herein and when immediately followed by a numerical designation refer to various polypeptides, wherein the complete designation (i.e., PRO/number) refers to specific polypeptide sequences as described herein. The terms “PRO/number polypeptide” and “PRO/number” wherein the term “number” is provided as an actual numerical designation as used herein encompass native sequence polypeptides and polypeptide variants (which are further defined herein). The PRO polypeptides described herein may be isolated from a variety of sources, such as from human tissue types or from another source, or prepared by recombinant or synthetic methods.

#A “native sequence PRO polypeptide” comprises a polypeptide having the same amino acid sequence as the corresponding PRO polypeptide derived from nature. Such native sequence PRO polypeptides can be isolated from nature or can be produced by recombinant or synthetic means. The term “native sequence PRO polypeptide” specifically encompasses naturally-occurring truncated or secreted forms of the specific PRO polypeptide (e.g., an extracellular domain sequence), naturally-occurring variant forms (e.g., alternatively spliced forms) and naturally-occurring allelic variants of the polypeptide. In various embodiments of the invention, the native sequence PRO polypeptides disclosed herein are mature or full-length native sequence polypeptides comprising the full-length amino acids sequences shown in the accompanying figures. Start and stop codons are shown in bold font and underlined in the figures. However, while the PRO polypeptide disclosed in the accompanying figures are shown to begin with methionine residues designated herein as amino acid position 1 in the figures, it is conceivable and possible that other methionine residues located either upstream or downstream from the amino acid position 1 in the figures may be employed as the starting amino acid residue for the PRO polypeptides.

Secreted and transmembrane polypeptides and nucleic acids encoding the same

Life of this patent

Secreted and transmembrane polypeptides and nucleic acids encoding the same

Life of this patent

Life of this patent

Abstract

Drawings

Drawings

Claims57

Description176,462 words

Drawings

Classification15 codes

Life of this patent

Description176,462 words