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US 2003/0194405 A1Published application
Antibody inhibiting stem cell factor activity and use for treatment of asthma
AssigneeBayer Aktiengesellschaft
InventorsToshihiko Takeuchi, Adrian Tomkinson, Steven Neben
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Abstract
The present invention provides human antibodies specific for stem cell factor that contain at least one CDR derived from a combinatorial antibody library. The invention also provides pharmaceutical compositions comprising the antibodies and methods of treating asthma. The invention further provides methods of detecting stem cell factor using the antibodies.
Claims22
A purified human antibody which binds to stem cell factor protein, said antibody comprising
- a light chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 19-24 or
- a heavy chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 13-18,
- said antibody being optionally bound to a cytotoxic molecule or detectable label.
2 more elements
Dependencies are inferred from the claim text.