Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same

A nucleic acid molecule comprising a nucleotide sequence encoding an amino acid sequence selected from the group consisting of:

• (a) the amino acid sequence set forth in SEQ ID NO:
• 2, with or without the signal peptide;
• (b) the amino acid sequence shown in SEQ ID NO:
• 6;
• (c) the amino acid sequence from residue 50-127 of SEQ ID NO:
• 2;
• and
• (d) the CDR1, CDR2 and CDR3 amino acid sequences shown in SEQ ID NOS:
• 8, 10, AND 12, respectively.

A nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

• (a) the nucleotide sequence from nucleotide 1-709, 1102-1137, 1256-1585, and 1683-2002 of SEQ ID NO:
• 1;
• (b) the nucleotide sequence from nucleotide 58-709, 1102-1137, 1256-1585, and 1683-2002 of SEQ ID NO:
• 1;
• (c) the nucleotide sequence from nucleotide 58-709 of SEQ ID NO:
• 1;
• (d) the nucleotide sequence from nucleotide 148 to 381 of SEQ ID NO:
• 1;
• and
• (e) the nucleotide sequence from nucleotide 1 to 2002 of SEQ ID NO:
• 1.

A nucleic acid molecule comprising a nucleotide sequence encoding an amino acid sequence selected from the group consisting of:

• (a) the amino acid sequence set forth in SEQ ID NO:
• 4, with or without the signal peptide;
• (b) the amino acid sequence from residue 23-130 of SEQ ID NO:
• 4;
• (c) the amino acid sequence from residue 46-119 of SEQ ID NO:
• 4;
• and
• (d) the CDR1, CDR2 and CDR3 amino acid sequences shown in SEQ ID NOS:
• 14, 16, and 18, respectively.

A nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:

• (a) the nucleotide sequence set forth in SEQ ID NO:
• 3;
• (b) the nucleotide sequence from nucleotide 67-708 set forth in SEQ ID NO:
• 3;
• (c) the nucleotide sequence from nucleotide 67-390 set forth in SEQ ID NO:
• 3;
• and
• (d) the nucleotide sequence from nucleotide 67-357 set forth in SEQ ID NO:
• 3.