Vaccine
OwnerClaire Ashman, James Scott Crowe +2inventors
InventorsClaire Ashman, James Scott Crowe, Jonathan Henry Ellis, Alan Peter Lewis
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Abstract
The present invention relates to an isolated polypeptide useful for immunisation against self-antigens. In particular the invention relates to a self-protein that is capable of raising auto-antibodies when administered in vivo. The invention particularly relates to rendering human cytokines immunogenic in humans. The invention further relates to pharmaceutical compositions comprising such compounds and their use in medicine and to methods for their production.
Claims25
An isolated protein which is at least 30% but less than 100% identical to a human protein which polypeptide
- (a) contains at least one mutation which is characteristic of an analogous non-human protein;
- (b) is capable of raising antibodies in human
- (c) is sufficiently structurally similar to the human protein that the antibodies bind to both the human protein and the polypeptide and;
- wherein the protein is not an antibody.
A protein having B-cell epitopes from a mammalian self-antigen and a mutation that gives rise to a sequence of an analogous protein of a second mammalian species such that the protein is able to raise in the species from which the B-cell epitopes derived, an immune response that recognises the natural protein from which the B-cell epitopes are derived.
A protein having B-cell epitopes of a self-protein which are grafted, by substitution, into a frame work of an analogous protein from a second mammalian species such that the protein is able to raise in the species in which the B-cell epitopes are derived, an immune response that recognises the natural protein from which the B-cell epitopes are derived.
A mutated human—IL-13 having one or more of the following substitutions or a substitution involving a conservative substitution thereof:
- 19 R → K at position 30 V → S at position 37 Y → F at position 63 A → V at position 65 E → D at position 68 E → Y at position 80 K → R at position 81 M → I at position 85 G → H at position 87 Q → H at position 113 V → I at position 115 D → K at position 117
A mutated human IL-13 as shown in FIG. 9.
Dependencies are inferred from the claim text.