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AssigneeBracco International B.V.
InventorsMichel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
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Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
An ultrasound contrast agent comprising an aqueous solution and surfactant stabilized microbubbles, the microbubbles comprising a halogenated hydrocarbon.
An ultrasound contrast agent comprising an aqueous solution and surfactant stabilized microbubbles, the microbubbles comprising a halogenated hydrocarbon and air.
An ultrasound contrast agent comprising an aqueous solution and surfactant stabilized microbubbles, the microbubbles comprising a halogenated hydrocarbon and nitrogen.
Dependencies are inferred from the claim text.