Compositions including a visual marker and method of use thereof
AssigneeXanodyne Pharmacal, Inc.
InventorsRalph A. Heasley, Gilbert R. Gonzales, Roger D. Griggs
Life of this patent
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Abstract
Compositions and method including a visual marker for monitoring patient compliance with a medication regimen. The marker is formulated with a rapid dissolve layer and adhered to, or ingested with, an orally administrable medicament. Upon ingestion, the marker is released causing a detectable marker-induced property in the oral and/or pharyngeal cavity of a subject. By examining the patient's oral and/or pharyngeal cavity and articles associated with the patient, one can determine whether the medicament has been ingested based upon the presence or absence of the property. The composition is also useful for tracking the location of an un-ingested medicament.
Claims84
A composition comprising at least one detectable marker formulated with a rapid dissolve layer, the composition adapted to be placed on an orally administrable medicament and to release at least one marker from the rapid dissolve layer upon exposure to saliva.
A medicament formulation comprising an ingestible medicament and a detectable marker contained thereon for patient compliance of the medicament, the marker formulated with a rapid dissolve layer.
A kit for monitoring patient compliance with dosing of a medicament, the kit comprising a marker formulated with a rapid dissolve layer in a composition adapted to be placed on a surface of a medicament and to release the marker upon exposure to saliva.
A method of tracking an ingestible medicament comprising
- providing to a patient a medicament for ingestion, the medicament containing a compliance marker formulated with a saliva-activated rapid dissolve layer;
- and
- examining the patient for a marker-induced property to track the medicament.
A method for monitoring patient ingestion of a medicament comprising:
- providing to a patient a medicament for ingestion, the medicament containing a compliance marker formulated with a saliva-activated rapid dissolve layer;
- and
- examining an oral and/or pharyngeal cavity of the patient for a marker-induced property to determine ingestion of the medicament.
A method for tracking the location of a medicament comprising
- providing to a patient a medicament with a marker-containing rapid dissolve layer and a friable first layer overlying the rapid dissolve layer;
- and
- examining at least one of the patient and an article associated with the patient for a marker-induced property to determine location of the medicament.
Dependencies are inferred from the claim text.