Radioimaging probes and the use thereof
OwnerHu Liu, Lili Wang +2inventors
InventorsHu Liu, Lili Wang, Wu Xiao, Ping Liu
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Abstract
The present invention provides novel radioimaging probes for use in combination with clinical radioimaging techniques for the visualization of specific tissues or regions of the body. These probes can be packaged into a blood-borne delivery vehicle for targeted delivery to these specific tissues or regions. This invention further provides for the use of synthetic microemulsions or chemically modified human low-density lipoprotein (LDL), such as acetylated LDL (AcLDL), as delivery vehicles to target the radioimaging probes specifically to tissues or regions that contain high concentrations of LDL receptors.
Claims29
A compound of the formula (I):
- 13
- wherein:
- n is an integer between 1 and 16;
- each R group is independently H or I, wherein between 2 to 6 R groups must I;
- R′ and R″ are independently H, (C1-C4 alkyl) or an amine protecting group;
- R1 is H, (C1-C6) alkyl, wherein said alkyl is optionally substituted with alkyl, aryl, or cycloalkyl;
- R2 is H;
- R3 is H or when taken together R2 and R3 is ═O;
- and
- R4 is:
- 14
- wherein:
- the bond - - - designates a single or a double bond;
- R5 is H, OR′″ or R′″, wherein R′″ is (C1-C6) alkyl;
- R6 is H or absent;
- R7 is H or absent;
- R8 is H, (C1-C6) alkyl or (C2-C6) alkenyl;
- R9 is H or absent;
- R10 is H or absent;
- R11 and R12 are independently H, R′″ or OR′″, or when taken together R11 and R12 are ═O;
- with the proviso that when R9 and R10 are absent and the bond - - - between carbon atoms bearing R9 and R10 is a double bond, then R8 is H or (C1-C6) alkyl;
- and that two adjacent bonds designated as - - - are not double bond at the same time.
A compound of the structure:
- (C2I)
- 15
Dependencies are inferred from the claim text.