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US 2003/0192791 A1Published application
Closure device for a medical container
AssigneeAstraZeneca AB
InventorsArne Eek, Billy Nilsson
Life of this patent
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AssigneeAstraZeneca AB
InventorsArne Eek, Billy Nilsson
Estimating the term…
A closure device is designed for attachment on a neck portion (1) of a separate container (2), preferably of glass material, which holds a first substance. The closure device defines a passage (10) extending between opposite first and second openings (11, 13) of the closure device. A sealing means (30) is arranged to close off the first opening (11) and confine a second substance in the passage (10). A penetration means (33) is incorporated in the device and operable to penetrate the sealing means (30) such that fluid communication is established between the passage (10) and the container (2). In a method of mixing the first and second substances, a medical practitioner exposes the second opening (13) by removing a non-resealable cap (8), by introducing and engaging the end of a syringe directly in the second opening (13), and by operating the penetration means (33) to penetrate the sealing means (30). By operating the syringe, the practitioner can transfer the first and second substances to the syringe, and mix the same in the process, with minimum need for sterilization.
A closure device for attachment on a neck portion (1) of a container (2) holding a first substance, said closure device comprising a first end portion (4) and a second end portion (6), a first opening (11) being defined in the first end portion (4), a second opening (13) being defined in the second end portion (6), and a passage (10) extending within said closure device for fluid communication between the first and second openings (11, 13), characterized by a sealing means (30;
A closure device according to any one of the preceding claims, wherein said sealing means comprises a breakable foil (30), preferably of aluminum material or an aluminum laminate, which is arranged to close off the first opening (11).
A closure device according to any one of the preceding claims, which is adapted to be directly mounted in an opening defined by the neck portion (1) of the container (2).
A closure device according to any one of the preceding claims, wherein the passage (10) comprises a conduit (31) extending from the second opening (13), and a chamber (32) communicating with the conduit (31) and the first opening (11), and wherein the penetration means (33;
A closure device according to any one of the preceding claims, wherein the passage (10) is defined in a body (3) comprising a sleeve element (4, 5) and a lid element (6) including the second opening (13), the lid element (6) being attached to an open end of the sleeve element (4, 5) to define the passage (10).
A closure device according to any one of the preceding claims, wherein the second end portion (6) at the second opening (13) comprises a Luer fitting, such as a Luer Slip fitting or a Luer Lock fitting.
A closure device according to any one of the preceding claims, which is of unitary construction and adapted to be attached to the neck portion (1) of the container (2).
A closure device according to any one of the preceding claims, wherein a non-resealable cap (8) is provided at the second end portion (6) to seal the second opening (13).
A closure device according to any one of the preceding claims, wherein said second substance is a pH-lowering substance, such as HCl, or a local anaesthetic, such as lidocaine or ropivacaine.
A closure device according to any one of the preceding claims, wherein said first substance in the container (2) is a pharmaceutically active drug, preferably propofol.
Dependencies are inferred from the claim text.