Direct arterial infiltration for production of vascular pathology
OwnerElazer Edelman, Campbell Rogers +1inventors
InventorsElazer Edelman, Campbell Rogers, Frederick G. Welt
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Abstract
A method of producing a vascular lesion in an animal that resembles atherosclerosic lesions in humans. The method includes introducing cholesterol enriched with LDL or cholesterol enriched with LDL and monocytes, macrophages, leukocytes, smooth muscle cells or platelets into a proliferative lesion created by standard methods, to promote atherosclerosis.
Claims15
A method of producing a vascular lesion in an animal that resembles atherosclerosic lesions in humans, said method comprising:
- introducing materials such as cholesterol enriched with LDL or cholesterol enriched with LDL and monocytes, macrophages, leukocytes, smooth muscle cells or platelets into or around a proliferative lesion to promote atherosclerosis.
A method of producing a vascular lesion in an animal, which resembles atherosclerosic lesions in humans, said method comprising:
- feeding the animal a hyperlipidemic diet;
- denuding arterial segments of the animal to produce a proliferative lesion;
- and
- introducing cells into said proliferative lesion to promote atherosclerosis.
A method of healing lesions within the walls of tubular tissues through the introduction of cells, cell elements and chemical or pharmacological compounds from the lumen of the tubular tissue into the wall of the tubular tissue.
Dependencies are inferred from the claim text.