Apparatus for inducing an immune response in cancer therapy
OwnerVladimir Kalina, Pavel Richter +1inventors
InventorsVladimir Kalina, Pavel Richter, Vratislav Horak
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Abstract
A device for inducing an immune response in cancer therapy in which isolated living malignant tissue is enclosed in a space formed by a microporous membrane in a holder which is introduced into a body cavity so that macromolecular and cellular immune system components can pass freely in both directions through the membrane while malignant cells of the tumor tissue remain trapped inside.
Claims20
A device for inducing a generalized immune response against primary solid tumors and metastases in cancer therapy that acts by enclosing autologous living malignant tissue in an inhibitive ischemic environment formed by a porous membrane inside a holder which can take any suitable anatomically compatible shape when introduced either partially or integrally at an implantation site in a body cavity, wherein the membrane has pores larger than 2 microns but smaller than the mean size of the cells of the biological tissue which is enclosed in the holder and wherein the size of the pores is specifically chosen so that all forms of large immunologically active leucocytes can pass freely in and out of the holder while smaller malignant cells of specific tumors remain safely trapped inside without the risk of their secondary dissemination at the implantation site.
A method for inducing an immune response against malignant cells and tumors in cancer therapy, which comprises enclosing living malignant biological tissue in a space formed by a microporous membrane inside a holder which is introduced either partially or integrally into a body cavity.
Dependencies are inferred from the claim text.