Hypoglycemic agent
AssigneeAjinomoto Co., Inc.
InventorsHiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura, Niro Inaba, Kazuhiro Kojima, Hideki Kosono
Life of this patent
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Abstract
The present invention provides a hypoglycemic agent containing an acylsulfonamide derivative such as a compound of the following formula or an analog thereof, which agent is usable for preventing and curing diabetes: 1
Claims24
A hypoglycemic agent containing an acylsulfonamide derivative(s) of the following general formula (I) as the active ingredient(s):
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- wherein R1 represents a substituted or unsubstituted C1 to C12 alkyl group, a substituted or unsubstituted C2 to C12 alkenyl group, a substituted or unsubstituted C2 to C12 alkynyl group or a substituted or unsubstituted C1 to C12 alkoxyl group, R2 represents hydrogen atom, hydroxyl group, mercapto group, a substituted or unsubstituted C1 to C6 alkoxyl group, a substituted or unsubstituted C1 to C6 alkylthio group, nitro group, a halogen atom, trichloromethyl group, trifluoromethyl group or cyano group, R3 represents a substituted or unsubstituted C1 to C20 alkyl group, a substituted or unsubstituted C2 to C20 alkenyl group, a substituted or unsubstituted C2 to C20 alkynyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, a substituted amino group, a substituted or unsubstituted C1 to C20 alkoxyl group, a substituted or unsubstituted C2 to C20 alkenyloxyl group, a substituted or unsubstituted C2 to C20 alkynyloxyl group or a group of the formula:
- R4O—, wherein R4 represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group, Y represents a group of the formula:
- —CH═CH—, —N═CH— or —CH═N—, sulfur atom or oxygen atom, and ring A represents a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group or a substituted or unsubstituted cycloalkyl group.
A hypoglycemic agent containing a compound having an activity of inhibiting acetyl CoA carboxylase as an active ingredient.
An agent for improving insulin resistance, which contains a compound having an activity of inhibiting acetyl CoA carboxylase as an active ingredient.
Dependencies are inferred from the claim text.