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US 2003/0191321 A1Published application
Process for the preparation of thiazole derivatives
AssigneeSyngenta Crop Protection AG
InventorKevin Coppola
Life of this patent
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Abstract
The present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethylthiazole which is a known compound useful for the preparation of insecticides.
Claims11
The compound having the formula
- 4
- and acid addition salts thereof.
The 5-hydroxythiazole-2-diazonium salt compound of formula
- 5
- and acid addition salts thereof, wherein A− is a counter-anion derived from an acid HA, wherein HA is an organic acid or inorganic mineral acid.
A process for preparing the compound having the formula
- 6
- and acid addition salts thereof, comprising the step of reacting 2-chloro-5-hydroxymethylthiazole having the formula
- 7
- with chloride anion source in the presence of acid.
1 more element
A process for preparing the compound having the formula:
- 8
- and acid addition salts thereof, comprising the step of reacting 2-hydroxy-5-hydroxymethylthiazole having the formula:
- 9
- with a chloride anion source in the presence of an acid.
1 more element
A process for preparing the compound having the formula:
- 10
- and acid addition salts thereof, comprising the step of reacting the 5-hydroxymethyl -thiazole-diazonium salt of formula
- 11
- wherein A− is a counter-anion derived from an acid HA, wherein HA is an organic acid or inorganic mineral acid, with chloride anion source in the presence of acid.
1 more element
A process for preparing the 5-hydroxymethylthiazole-diazonium salt of formula
- 12
- wherein A− is a counter-anion derived from an acid HA, wherein HA is an organic acid or inorganic mineral acid, comprising the step of reacting a compound having the formula:
- 13
- and acid addition salts thereof, with an alkali metal nitrite in the presence of acid.
1 more element
A process of preparing the compound having the formula:
- 14
- comprising the step of reacting an epoxide compound of formula:
- 15 with thiourea.
Dependencies are inferred from the claim text.