Ester derivatives

22) Compounds represented by a general formula (II):

• 59
• [in which Ap signifies a group represented by a formula (ap0) or (bp0)
• 60
• Ar signifies aryl or heteroaryl optionally having substituent(s) selected from a group consisting of halogen, lower alkyl, lower alkenyl and lower alkoxy;
• B1 and B2 signify, independently of each other, straight chain, branched chain and/or cyclic portion-containing C2-C10 saturated or unsaturated aliphatic hydrocarbon which may have hydroxyl group(s) and/or be interrupted with nitrogen atom(s);
• R1 signifies a fluorine-substitured C4-C6 cycloalkyl optionally having hydroxyl group(s);
• R20 signifies hydrogen or a lower alkyl optionally having substituent(s) selected from a group consisting of phenyl and cycloalkyl;
• R40 signifies lower alkyl which may have substituent(s) selected from a group consisting of phenyl and cycloalkyl, or a single bond or a C1-C3 alkylene group binding to a bindable optional site on B1;
• R5 signifies hydrogen or a lower alkyl optionally having substituent(s) selected from a group consisting of phenyl and cycloalkyl, or a single bond or a C1-C3 alkylene binding to a bindable optional site on B2] or salts thereof.

40) Treating agents of diseases associated with muscarine M3 receptors, which contain as the active ingredient, compounds which are represented by the following general formula (I):

• 70
• [in which A signifies a group expressed by a formula (a0) or (b0);
• 71
• Ar signifies aryl or heteroaryl optionally having substituent(s) selected from a group consisting of halogen, lower alkyl, lower alkenyl and lower alkoxy;
• B1 and B2 signify, independently of each other, straight chain, branched chain and/or cyclic portion-containing C2-C10 saturated or unsaturated aliphatic hydrocarbon which may have hydroxyl group(s) and/or be interrupted with nitrogen atom(s);
• R1 signifies a fluorine-substituted C4-C6 cycloalkyl optionally having hydroxyl group(s);
• R2, R3 and R4 signify, either independently of each other, a lower alkyl optionally having substituent(s) selected from a group consisting of phenyl and cycloalkyl, or R2 and R3 together signify a C2-C5 alkylene which may be interrupted with oxygen;
• or R4 signifies a single bond or a C1-C3 alkylene binding to a bindable optional site on B1;
• R5 signifies hydrogen or a lower alkyl optionally having substituent(s) selected from a group consisting of phenyl and cycloalkyl and R7 signifies hydrogen or a lower alkyl, or either one of R5 and R7 signifies a single bond or a C1-C3 alkylene binding to a bindable optional site on B2;
• R6 signifies hydrogen, lower alkyl or a group represented by —N(R8)R9;
• R8 and R9 signify, independently of each other, hydrogen or lower alkyl;
• and X− signifies an anion] or salts thereof.

41) Treating agent of chronic obstructive pulmonary diseases, chronic bronchitis, asthma, chronic respiratory tract obstruction, fibroid lung, pulmonary emphysema or rhinitis, which contain as the active ingredient, compounds which are represented by the following general formula (I):

• 72
• [in which A signifies a group expressed by a formula (a0) or (b0);
• 73
• Ar signifies aryl or heteroaryl optionally having substituent(s) selected from a group consisting of halogen, lower alkyl, lower alkenyl and lower alkoxy;
• B1 and B2 signify, independently of each other, straight chain, branched chain and/or cyclic portion-containing C2-C10 saturated or unsaturated aliphatic hydrocarbon which may have hydroxyl group(s) and/or be interrupted with nitrogen atom(s);
• R1 signifies a fluorine-substituted C4-C6 cycloalkyl optionally having hydroxyl group(s);
• R2, R3 and R4 signify, either independently of each other, a lower alkyl optionally having substituent(s) selected from a group consisting of phenyl and cycloalkyl, or R2 and R3 together signify a C2-C5 alkylene which may be interrupted with oxygen;
• or R4 signifies a single bond or a C1-C3 alkylene binding to a bindable optional site on B1;
• R5 signifies hydrogen or a lower alkyl optionally having substituent(s) selected from a group consisting of phenyl and cycloalkyl and R7 signifies hydrogen or a lower alkyl, or either one of R5 and R7 signifies a single bond or a C1-C3 alkylene binding to a bindable optional site on B2;
• R6 signifies hydrogen, lower alkyl or a group represented by —N(R8)R9;
• R8 and R9 signify, independently of each other, hydrogen or lower alkyl;
• and X− signifies an anion] or salts thereof.