Method for producing lamotrigine from alpha-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone by ring closure reaction

Method according to one of the preceding claims, in which the cyclization reaction is performed using an acid addition salt, preferably the dihydrochloride of the compound of formula XII.

Method according to one of the preceding claims, in which the compound of formula XII or a salt thereof is obtained by reacting a compound of formula XI

• 12
• in which R is a substituted or unsubstituted straight- or branched-chained, or cyclical alkyl-, aryl- or aralkyl-residue, or a salt thereof, with aminoguanidine or a salt thereof.

Compound of formula IX

• 15
• in which R is a substituted or unsubstituted straight- or branch-chained, or cyclical alkyl-, aryl-, or aralkyl-residue, or a salt thereof.

Compound of formula X

• 16
• in which R is a substituted or unsubstituted straight- or branch-chained, or cyclical alkyl-, aryl-, or aralkyl-residue, or a salt thereof.

Compound of formula XI

• 17
• in which R is a substituted or unsubstituted straight- or branch-chained, or cyclical alkyl-, aryl-, or aralkyl-residue, or a salt thereof.

Compound of formula XII

• 18
• or a salt thereof.

Use of a compound of formula IX

• 19
• in which R is a substituted or unsubstituted straight- or branch-chained, or cyclical alkyl-, aryl-, or aralkyl-residue, or a salt thereof for producing lamotrigine or a pharmaceutically acceptable salt thereof.

Use of a compound of formula X

• 20
• in which R is a substituted or unsubstituted straight- or branch-chained, or cyclical alkyl-, aryl-, or aralkyl-residue, or a salt thereof for producing lamotrigine or a pharmaceutically acceptable salt thereof.

Use of a compound of formula XI

• 21
• in which R is a substituted or unsubstituted straight- or branch-chained, or cyclical alkyl-, aryl-, or aralkyl-residue, or a salt thereof for producing lamotrigine or a pharmaceutically acceptable salt thereof.

Use of a compound of formula XII

• 22
• or a salt thereof for producing lamotrigine or a pharmaceutically acceptable salt thereof.