Filtration
AssigneeOctapharma AG, a Corporation of Switzerland
InventorStefan Winge
Life of this patent
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Abstract
Filtration methods comprise virus-filtering a solution containing a least one macromolecule. The total salt content of the solution for virus-filtering is within the range of from about 0.2 M up to saturation with the salt. Salts that can be used in the filtering methods include sodium chloride, potassium chloride, sodium acetate, sodium citrate, sodium phosphate, potassium dyhydrophosphate and combinations thereof.
Claims12
A method of virus-filtering a solution containing at least one macromolecule, characterized in that the total salt content of the solution lies within the range of from about 0.2 M up to saturation of the solution with the salt concerned.
A method according to any previous claim, characterized in that the salt is selected from the group consisting of sodium chloride, potassium chloride, sodium acetate and sodium citrate and combinations thereof.
A method according to any previous claim, characterized in that the macromolecule is selected from the group consisting of proteins, polysaccharides and polypeptides and combinations thereof.
A method according to any previous claim, characterized in that the virus-filtering process is carried out in accordance with the “dead-end” filtering technique.
A method according to any previous claim, characterized in that the virus-filtering process reduces the content of non-enveloped viruses by at least 4 logs.
Dependencies are inferred from the claim text.