Urea derivatives useful as anticancer agents

A compound of the formula

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• or a pharmaceutically acceptable salt, hydrate or prodrug thereof, wherein:
• R1 and R5 are each independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CH2)t(C6-C10 aryl), or —(CH2)t(4 to 10 membered heterocyclic), wherein t is an integer from 0 to 5;
• said alkyl group optionally including 1 or 2 hetero moieties selected from O, S and —N(R6)— with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other;
• said aryl and heterocyclic R1 and R5 groups being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4 to 10 membered heterocyclic group;
• one or two carbon atoms in said 4 to 10 membered heterocyclic group of R1 and R5 being optionally substituted by an oxo (═O) moiety;
• the —(CH2)t— moieties of R1 and R5 optionally including a carbon-carbon double or triple bond when t is an integer from two to five;
• R1 and R5 groups being optionally substituted by one to five R6 groups;
• each R6 is independently selected from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, halo, cyano, nitro, trifluoromethyl, trifluoromethoxy, azido, —OR7, —C(O)R8, —C(O)OR7, —NR8C(O)OR7, —OC(O)R7, —NR8SO2R7, —SO2NR7R8, —NR8C(O)R7, —C(O)NR7R8, —NR7R8, —S(O)jR9 wherein j is an integer ranging from zero to two, —SO3H, —NR7(CR8R9)tOR8, —(CH2)t(C6-C10 aryl), —SO2(CH2)t(C6-C10 aryl ), —S(CH2)t(C6-C10 aryl), —O(CH2)t(C6-C10 aryl), —(CH2)t(4 to 10 membered heterocyclic), and —(CR8R9)mOR8 wherein m is an integer from one to five and t is an integer from zero to five;
• said alkyl group optionally containing one or two hetero moieties selected from O, S and —N(R8)— with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other;
• aryl and heterocyclic moieties of R6 being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4 to 10 membered heterocyclic group;
• one or two carbon atoms of the heterocyclic moieties of R6 being optionally substituted by an oxo (═O) moiety;
• and the alkyl, aryl and heterocyclic moieties of R6 groups being optionally substituted by one to three substituents independently selected from halo, cyano, nitro, trifluoromethyl, trifluoromethoxy, azido, —NR8SO2R7, —SO2NR7R8, —C(O)R7, —C(O)OR7, —OC(O)R7, —NR8C(O)R7, —C(O)NR7R8, —NR7R8, —(CR8R9)mOR8 wherein m is an integer from one to five, —OR7 and R7;
• each R7 is independently selected from H, C1-C10 alkyl, —(CH2)t(C6-C10 aryl), and —(CH2)t(4 to 10 membered heterocyclic), wherein t is an integer from zero to five;
• said alkyl group optionally including one or two hetero moieties selected from O, S and —N(R6)— with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other;
• said aryl and heterocyclic R groups being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4 to 10 membered heterocyclic group;
• the foregoing moieties of R7;
• with the exception of H, being optionally substituted by one to three substituents independently selected from halo, cyano, nitro, trifluoromethyl, trifluoromethoxy, azido, —C(O)R8, —C(O)OR8, —CO(O)R8, —NR8C(O)R9, —C(O)NR8R9, —NR8R9, hydroxy, C1-C6 alkyl, and C1-C6 alkoxy;
• each R8 and R9 is independently H or C1-C6 alkyl;
• R2 is a group selected from CO2H, CONHSO2R1, CONR1(CH2)CO2H, SO2H, PO3H2,
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• each R3 is independently selected from H and R2;
• R4 is —(CH2)t(C6-C10 aryl), or —(CH2)t(4 to 10 membered heterocyclic), wherein t is a integer from zero to five;
• said alkyl group optionally including one or two hetero moieties selected from O, S and —N(R6)— with the proviso that two O atoms, two S atoms, or an O and S atom are not attached directly to each other;
• said aryl and heterocyclic R4 groups are optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4 to 10 membered heterocyclic group;
• one or two carbon atoms of the heterocyclic moieties of R4 being optionally substituted by an oxo (═O) moiety;
• the —(CH2)t— moieties of R4 optionally including a carbon-carbon double or triple bond where t is an integer from two to five, R4 being optionally substituted by one to five R6 groups or methylenedioxy;
• R10 and R11 are each independently R1, or R10 and R11, together with the carbons to which R10 and R11 are attached, optionally form a 4 to 10 membered carbocyclic group optionally substituted by ═O or H(OH) or a 4 to 10 membered heterocyclic group comprising heterocyclic moieties selected from O, N or S optionally substituted with R1, S, SO or SO2;
• said carbocyclic group or heterocyclic group formed by R10 and R11 being optionally fused to a C6-C10 aryl group, a C5-C8 saturated cyclic group, or a 4 to 10 membered heterocyclic group optionally substituted with one or more substituents selected from halogen, hydroxy, C1-C10 alkyl, C1-C10 alkoxy and methylenedioxy;
• Y and Z are independently CH, N optionally substituted with R1, O, S, SO or SO2;
• m is zero or 1;
• n is zero or 1;
• b is zero or 1;
• v is zero or 1 and
• p is zero to 6,
• with the proviso that said compound of formula I is not 3-(3-{[benzyl-(2-benzyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-carbamoyl]-methyl}-ureido)-benzoic acid or 3-(3-{[2(2-benzyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-isoxalol-5-ylmethyl-carbamoyl]-methyl}-ureido)-benzoic acid.