Compounds that stimulate glucose utilization and methods of use

A pharmaceutical composition comprising at least one compound represented by Formula (I), or Formula (II):

• 58
• wherein
• W is C1-C6 alkyl, halogen, or aryl;
• Cyc is C3 or C4 cycloalkyl;
• p is 0-3 for Cyc being C4 cycloalkyl, or p=0-2 for Cyc being C3 cycloalkyl;
• Y is O, S, or NR, where R═H, alkyl or aryl;
• X is O, S, NR, or CR3R4;
• Z is H, alkyl, cycloalkyl, aryl or (cyclo)alkylcarbonyl;
• R1 is H, alkyl, aryl or O;
• R2 is H, alkyl or aryl;
• R3 and R4 are, independently, H, alkyl or aryl;
• and
• n is an integer from 1 to 10;
• or a pharmaceutically acceptable salt, ester or prodrug thereof;
• and
• a pharmaceutically acceptable carrier, diluent, excipient or mixtures thereof.

A method for increasing glucose utilization in a cell, tissue or organ of a warm blooded animal comprising treating said cell, tissue or organ with at least one compound represented by Formula (I) or Formula (II)

• 59
• wherein
• W is C1-C6 alkyl, halogen, or aryl;
• Cyc is C3 or C4 cycloalkyl;
• p is 0-3 for Cyc being C4 cycloalkyl, or p=0-2 for Cyc being C3 cycloalkyl;
• Y is O, S, or NR , where R═H, alkyl or aryl;
• X is O, S, NR, or CR3R4;
• Z is H, alkyl, cycloalkyl, aryl or (cyclo)alkylcarbonyl;
• R1 is H, alkyl, aryl or O;
• R2 is H, alkyl or aryl;
• R3 and R4 are, independently, H, alkyl or aryl;
• and
• n is an integer from 1 to 10;
• or a pharmaceutically acceptable salt, ester or prodrug thereof.

A method for treatment of physiological conditions or disorders treatable by increasing glucose utilization comprising:

• administering to a patient in need of such treatment, effective amounts of a pharmaceutical composition comprising at least one compound represented by Formula (I) or Formula (II)
• 60
• wherein
• W is C1-C6 alkyl, halogen, or aryl;
• Cyc is C3 or C4 cycloalkyl;
• p is 0-3 for Cyc being C4 cycloalkyl, or p=0-2 for Cyc being C3 cycloalkyl;
• Y is O, S, or NR, where R═H, alkyl or aryl;
• X is O, S, NR, or CR3R4;
• Z is H, alkyl, cycloalkyl, aryl or (cyclo)alkylcarbonyl;
• R1 is H, alkyl, aryl or O;
• R2 is H, alkyl or aryl;
• R3 and R4 are, independently, H, alkyl or aryl;
• and
• n is an integer from 1 to 10;
• or a pharmaceutically acceptable salt, ester or prodrug thereof.