Methods for administration of paclitaxel

#1. Field of the Invention

#This invention relates to compositions that may be used as pharmaceutical compositions, methods and kits, more particularly to improved pharmaceutical formulations for paclitaxel that include vitamin-E derivatives.

#2. Description of Related Art

#FIG. 1 shows Table 4 that summarizes results of the treatment of the nude mice with paclitaxel in 5% EVE, 5% EC and Clinical Taxol via i.v. injection.

#FIG. 2 shows Table 5 that summarizes results of toxicity studies of the nude mice treated with various paclitaxel formulations via i.v. injection.

#FIG. 3 shows Table 6 that summarizes results of toxicity studies of the nude mice treated with various paclitaxel formulations via oral administration.

#The present invention provides compositions, kits and methods for using paclitaxel for treating diseases associated with abnormal cell proliferation and angiogenesis. In particular, methods are provided for administration of paclitaxel formulated with vitamin E derivative to an animal, preferably a human. According to the present invention, administering to a patient paclitaxel in a vehicle containing a solubilizer other than Cremophor avoids adverse effects associated with Cremophor and may confer stronger therapeutic effects on the patient.

#1. Compositions of the Present Invention

#In the present invention, compositions are provided which are used for delivering paclitaxel in vivo. In one embodiment, the composition comprises paclitaxel, a solvent and a pharmaceutically-acceptable, water-miscible solubilizer selected from the group consisting of solubilizers having the general structures: