Substituted and unsubstituted benzooxathiazoles and compounds derived therefrom
AssigneeNone recorded
InventorsStefan Petry, Karl-Heinz Baringhaus, Swen Hoelder, Guenter Mueller
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AssigneeNone recorded
InventorsStefan Petry, Karl-Heinz Baringhaus, Swen Hoelder, Guenter Mueller
Estimating the term…
The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydrobenzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments.
A compound of the formula I
Dependencies are inferred from the claim text.
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Thiadiazoles; Hydrogenated thiadiazoles: condensed with carbocyclic rings or ring systems
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
Term end not estimated
This application claims priority to German Patent Application 10038709.8-44, filed Aug. 9, 2000, which is hereby incorporated by reference, in its entirety.
1 Field of the Invention
The present invention relates to substituted and unsubstituted 3H-benzo-[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydrobenzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments
5 2 TABLE 1 Compound R1 R2 R3 X Y 1 7-H 6-H 5-H N N 2 7-H 6-H 5-CH3 N O 3 7-H 6-H 5-H O N 4 In positions 4 and 5, in each case two O N radicals R1 and R2 or R2 and R3 or R1 and R3 together form a fused benzene radical; the respective remaining radical located in position 7 or 6 is H 5 7-H 6-NO2 5-H O N 6 7-H 6-NH2 5-H O N 7 7-H 6-H 5-COO(CH3) O N 8 7-H 6-H 5-COOH O N 9 7-H 6-H 5-CON O N (CH2—CH2— phenyl-3,4-O- CH2-phenyl) 10 7-H 6-H 5-CON O N (CH2-phenyl-4- O—(CH2)7—CH3) 11 7-H 6-H 5-CON O N ((CH2)15—CH3) 12 7-H 6-H 5-COO(CH3) N O 13 7-H 6-H 5-COOH N O 14 7-H 6-H 5-CON N O (CH2—CH2— phenyl-3,4-O- CH2-phenyl) 15 7-H 6-H 5-CON N O (CH2- benzimidazolyl -2,5-S-phenyl)
Inhibitors of phosphatases are described, inter alia, in WO97/3974 (cinnamic acid derivatives as inhibitors of PTP) which is hereby incorporated herein by reference. Unspecific phosphatase inhibition by vanadium oxo complexes and other vanadium complexes results in improved insulin resistance.
Enzymatic test systems for detecting phosphatase inhibition