Macrolides
AssigneeNovartis AG
InventorsFrancois Navarro, Samuel Petit, Guy Stone
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Abstract
A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
Claims13
A mixture comprising a poly-ene macrolide and an antioxidant.
A process for stabilizing a polyene macrolide comprising adding an antioxidant to the purified macrolide.
40-O-(2-hydroxy)ethyl-rapamycin in crystalline form.
A pharmaceutical composition comprising a compound according to claim 11 or 12, together with one or more pharmaceutically acceptable diluents or carriers therefor.
A process for purifying 40-O-(2-hydroxy)ethyl-rapamycin, comprising crystallizing 40-O-(2-hydroxy)ethyl-rapamycin from a crystal bearing medium and recovering the crystals thus obtained.
Dependencies are inferred from the claim text.