Thieno[2,3-d]pyrimidinediones, their preparation and use in therapy

A compound of formula (I):

• 111
• wherein:
• R is —C(O)Ar1, —C(R4)(R5)Ar1, or Ar2;
• Ar1 is naphthyl, quinolyl, isoquinolyl, indolyl, benzofuranyl or benzothienyl, each of which can be optionally substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl, or Ar1 is phenyl optionally substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen, trifluoromethyl, amino, nitro, cyano, trifluoromethoxy, phenoxy, —CH2N(R6)2, —NHSO2CF3, C1-4alkylsulphonylamino, —NHC(O)R6a, CO2R7 or —C(O)NR8R8a;
• R4 represents H or C1-4 alkyl;
• R5 represents H or OH;
• each R6 independently represents H or C1-4 alkyl;
• R6a represents H, C1-6 alkyl, aryl or arC1-4alkyl, wherein the aryl group or aryl moiety in the aralkyl group is phenyl or pyridyl, each of which may be optionally substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, C1-4 alkylcarbonylamino, halogen or trifluoromethyl;
• R7 represents H or C1-4 alkyl;
• R8 and R8a each independently represent H, C1-4 alkyl, phenyl or pyridyl;
• Ar2 is acenaphthenyl, indanyl, iminodihydrobenzofuranyl or fluorenyl, each of which can be optionally substituted by one or more substituents selected from OH, C1-4 alkyl, C1-4 alkoxy, halogen, or trifluoromethyl;
• R1 and R2 are independently H, C1-6 alkyl, C3-6 alkenyl, CH2C3-5 cycloalkyl or C3-6 cycloalkyl;
• R3 represents H, X-R9 or X-Ar3;
• X represents S(O)n, C(O)NR10, C(O)O, NH(CO)NR10, NH(CO)O or SO2NR10;
• n is 0, 1 or 2;
• R9 represents a methyl group optionally substituted by one or more substituents selected from CN, CO2H, C1-5 alkoxycarbonyl, 5-tetrazolyl, SO2NH2 or C(O)NR11R12, or R9 represents C2-6 alkyl or C3-6 alkenyl, each of which may be optionally substituted by one or more substituents selected from OH, CN, CO2H, C1-5 alkoxy, C1-5 alkoxycarbonyl, 5-tetrazolyl, azide, phthalimido, SO2NH2, C(O)NR11R12, NR13R14, NHC(O)R15 or NHSO2R16 where R11, R12, R13 and R14 each independently represent H or C1-4 alkyl, R15 represents C1-4 alkyl, C1-4 alkoxy, di(C1-4alkyl)amino, or alkoxyalkylene containing up 6 carbon atoms, and R16 represents C1-4 alkyl or trifluoromethyl;
• or, additionally, in the case where X represents C(O)NR10, NH(CO)NR10 or SO2NR10, R9 and R10 together with the nitrogen atom to which they are attached may form a 4- to 7-membered heterocyclic ring which may be optionally substituted by one or more OH groups;
• R10 represents H, C1-6 alkyl or is linked to R9 as defined above;
• and
• Ar3 is phenyl, pyridyl or pyridine N-oxide, each of which may be optionally substituted by one or more substituents selected from OH, NO2, NH2, NHSO2CF3, C1-4 alkoxy, bis-C1-4alkanesulphonylamino, C1-4alkylcarbonylamino or C1-4alkoxycarbonylamino;
• or a p0 pharmaceutically-acceptable salt or solvate thereof.