Antiparkinsonism drugs
AssigneeShionogi & Co., Ltd.
InventorsShunji Shinohaea, Katsumi Koike
Life of this patent
Estimating the term…
Abstract
A compound represented by the formula: 1 wherein A is thiazolyl or the like, X is a bond or the like, m is an integer of 0 to 4, Y is optionally substituted alkyl or the like, Z is a substituent represented by the formula: 2 wherein R3 is hydrogen atom or the like, R4 and R5 are each independently hydrogen atom or the like, W is —(CH2)n— (n is 0,1,2 or 3) or the like, a prodrug thereof, its pharmaceutically acceptable salt, or its solvate is useful as a composition for prevention or treatment of Parkinson's disease.
Claims28
A pharmaceutical composition for prevention or treatment of Parkinson's disease, which contains as an active ingredient TRH or a TRH derivative.
A pharmaceutical composition enhancing an L-DOPA activity, which contains as an active ingredient TRH or a TRH derivative.
(Addition) A pharmaceutical composition enhancing an L-DOPA activity, which contains as an active ingredient a compound represented by formula (VIII):
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- wherein Y is optionally substituted alkyl, optionally substituted carboxy, cyano, or a substituent represented by the formula:
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- wherein R1 and R2 are independently hydrogen atom, or optionally substituted alkyl, or R1 and R2 taken together with the adjacent nitrogen may form a non-aromatic heterocyclic ring which may contain oxygen, nitrogen, or sulfur and may be substituted, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
(Addition) A pharmaceutical composition enhancing an L-DOPA activity, which contains as an active ingredient a compound represented by formula (IX):
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- its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
Dependencies are inferred from the claim text.