Methods and compositions for inhibition of angiogenesis
OwnerRobert J. D'Amatoinventor
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Abstract
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, antiinflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, these compounds can be administered orally.
Claims20
An angiogenesis inhibitory composition comprising an angiogenesis inhibiting compound and an antiinflammatory drug.
The angiogenesis inhibitory composition of claim 7 wherein the angiogenesis inhibiting compound has the formula
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- wherein R1-R4 are as defined in claim 8;
- R5 and R6 are independently selected from the group consisting of
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- and R9 is selected from F) or H) wherein R14 and R16 are each independently selected from the group consisting of
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- and R15 is
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- where R21 is H, CH3, or OH.
A method for inhibiting angiogenesis in a human or animal comprising administering to the human or animal a composition comprising a nonsteroidal, antiinflammatory drug (NSAID).
A method for inhibiting angiogenesis in a human or animal comprising administering to the human or animal a composition comprising an angiogenesis inhibiting compound and an antiinflammatory compound.
A method for treating an angiogenesis dependent disease in a human or animal having such a disease comprising administering to the human or animal a composition comprising a nonsteroidal, antiinflammatory drug (NSAID).
A method for treating an angiogenesis dependent disease in a human or animal having such a disease comprising administering to the human or animal a composition comprising an angiogenesis inhibiting compound and an antiinflammatory compound.
Dependencies are inferred from the claim text.