Pharmaceutical compositions comprising active vitamin D compounds
AssigneeNovacea, Inc.
InventorsAndrew X. Chen, Jun Fan, Xi-Yun Yu, Martha J. Whitehouse
Life of this patent
Estimating the term…
Abstract
Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.
Claims103
A pharmaceutical composition comprising:
- (a) a lipophilic phase component,
- (b) one or more surfactants, and
- (c) an active vitamin D compound;
- wherein said composition is an emulsion pre-concentrate, which, upon dilution with water in water to composition ratio of about 1:1 or more of said water, forms an emulsion having an absorbance of greater than 0.3 at 400 nm.
An oral pharmaceutical composition comprising:
- (a) a lipophilic phase component,
- (b) one or more surfactants, and
- (c) an active vitamin D compound;
- wherein said composition is an emulsion pre-concentrate, which, upon dilution with water in a water to composition ratio of about 1:1 or more of said water, forms an emulsion having an absorbance of greater than 0.3 at 400 nm.
A pharmaceutical composition comprising:
- (a) an active vitamin D compound,
- (b) a medium chain triglyceride,
- (c) tocopherol PEG-1000 succinate (vitamin E TPGS), and
- (d) GELUCIRE 44/14;
- wherein said composition is an emulsion pre-concentrate, which, upon dilution with water in water to composition ratio of about 1:1 or more of said water, forms an emulsion having an absorbance of greater than 0.3 at 400 nm.
A pharmaceutical composition comprising an active vitamin D compound, wherein said composition when administered to a subject provides a Tmax of less than about 6.0 hours and a T1/2 of less than about 25 hours.
Dependencies are inferred from the claim text.