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US 2003/0191067 A1Published application
Hepatitis C inhibitor tri-peptides
AssigneeBoehringer Ingelheim International GmbH
InventorsMontse Llinas-Brunet, Murray D. Bailey, Elise Ghiro
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Abstract
Compounds of formula (I): 1 wherein R1 is hydroxyl or sulfonamide derivative; R2 is t-butyl or —CH2—C(CH3)3 or —CH2-cyclopentyl; R3 is t-butyl or cyclohexyl and R4 is cyclobutyl, cyclopentyl or cyclohexyl; or a pharmaceutically acceptable salt thereof, are described as useful as inhibitor of the HCV NS3 protease.
Claims33
A compound of formula (I):
- 21
- wherein R1 is hydroxy or NHSO2RIA wherein RIA is (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl }, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O—(C1-6)alkyl, amido, amino or phenyl, or RIA is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O—(C1-6)alkyl, amido, amino or phenyl;
- R2 is t-butyl, —CH2—C(CH3)3, or —CH2-cyclopentyl;
- R3 is t-butyl or cyclohexyl and R4 is cyclobutyl, cyclopentyl, or cyclohexyl;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.