Peptide selection method
OwnerDavid Cameron Wraith, Stephen Mark Anderton +3inventors
InventorsDavid Cameron Wraith, Stephen Mark Anderton, Graziella Mazza, Mary Ponsford, Heather Barbara Streeter
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Abstract
There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing. There is also provided a peptide selected by such a method and its use in a pharmaceutical composition and a method to treat and/or prevent a disease.
Claims19
A method for selecting a tolerogenic peptide which comprises the step of selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing.
A method according to any preceding claim, wherein the peptide comprises a T cell epitope and presence of a T cell epitope is determined by:
- (i) treating:
- a sample of cells from a subject having the disease, and
- a sample of cells from a subject not having the disease with the peptide;
- and
- (ii) comparing the T cell responses between the cell samples.
A method according to any preceding claim which comprises the following steps:
- (i) treating an antigen processing independent presentation system (APIPS) with a peptide;
- and
- (ii) analysing binding of the peptide to MHC class I or II molecules within the APIPS.
A peptide selected by the method according to any preceding claim.
Dependencies are inferred from the claim text.