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OwnerErik Christenson, Anthony J. Demaggio +2inventors
InventorsErik Christenson, Anthony J. Demaggio, Phyllis S. Goldman, David L. McElligott
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The invention provides novel tankyrase polypeptides designated tankyrase2, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing the tankyrase2 polypeptides, antibodies that are immunoreactive with the tankyrase2 polypeptides. In addition, there are provided methods for identifying specific binding partners of tankyrase2, and more particularly methods for identifying binding partners that modulate biological activity of tankyrase2. Methods of modulating biological activity of tankyrase2 in vitro and in vivo are also provided.
A purified and isolated tankyrase2 polypeptide.
A method for identifying a binding partner of a tankyrase2 polypeptide, comprising:
A method for identifying a specific binding partner of a tankyrase2 polynucleotide, comprising:
A method of treating an animal having a medical condition mediated by poly(ADP-ribose) polymerase activity, comprising administering to said animal a tankyrase2 inhibitory compound in an amount effective for inhibiting tankyrase2 activity in said animal.
Dependencies are inferred from the claim text.